ArticleSchizophrenia research2020
Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms.
Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Sleep Abnormalities in Different Clinical Stages of Psychosis: A Systematic Review and Meta-analysis.JAMA psychiatry · 2023Pooled it
- Sleep as a moderator of adolescent brain development-evidence from a longitudinal MRI study.Sleep · 2026Article
- Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development.Npj biological timing and sleep · 2026Article
- Recent Evidence of Non-Rapid Eye Movement Sleep Oscillation Abnormalities in Psychiatric Disorders.Current psychiatry reports · 2025Review
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.Pediatric research · 2025Article
- OpenSpindleNet: An open-source deep learning network for reliable sleep spindle detection in scalp and intracranial EEG.Computers in biology and medicine · 2025Article
- Joint Heritability of Sleep EEG Spindle Activity and Thalamic Volume in Early Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Infraslow Fluctuation of Sigma Power During Sleep in Young Individuals with Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- The role of sleep disturbances in the onset and maintenance of psychiatric disorders in childhood and adolescence: A review of subjective and polysomnographic findings.Current sleep medicine reports · 2024Article
- Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.Molecular autism · 2024Article
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- The sleeping brain's connectivity and family environment: characterizing sleep EEG coherence in an infant cohort.Scientific reports · 2023Article
- Sleep spindles across youth affected by schizophrenia or anti-Frontiers in psychiatry · 2023Article
- Sleep spindles in people with schizophrenia, schizoaffective disorders or bipolar disorders: a pilot study in a general population-based cohort.BMC psychiatry · 2022Article
- Article
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Article
- Sleep Stage Classification Based on Multi-Centers: Comparison Between Different Ages, Mental Health Conditions and Acquisition Devices.Nature and science of sleep · 2022Article
- The Engram's Dark Horse: How Interneurons Regulate State-Dependent Memory Processing and Plasticity.Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Neuroimaging studies of childhood onset schizophrenia (COS), a rare yet severe form of schizophrenia with an onset before the age of 13 years, have shown continuity with adult onset schizophrenia. Previous research in adult patients has shown reduced sleep spindle activity, transient oscillations in the sleep electroencephalogram (EEG) generated through thalamocortical loops. The current study examines sleep spindle activity in patients with COS. Seventeen children and adolescents with COS (16 years ±6.6) underwent overnight sleep EEG recordings. Sleep spindle activity was compared between patients with COS and age and gender matched controls and correlated with clinical symptom severity. We found pronounced deficits in sleep spindle amplitude, duration, density and frequency in patients with COS (effect size = 0.61 to 1.96; dependent on metric and EEG derivation). Non-rapid eye movement (NREM) sleep EEG power and coherence in the sigma band (11-16 Hz) corresponding to spindle activity were also markedly diminished in patients with COS as compared to controls. Furthermore, the degree of deficit in power and coherence of spindles was strongly associated with clinician rated hallucinations and positive symptoms over widespread cortical regions. Our finding of diminished spindle activity and its association with hallucinations likely reflect dysfunction of the thalamocortical circuits in children and adolescents with COS. Given the relative ease of sleep EEG recordings in vulnerable populations, this study highlights the potential of such recordings to characterize brain function in schizophrenia.
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Registered trials
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