ArticleEBioMedicine2020
Clinical relevance of plasma virome dynamics in liver transplant recipients.
Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- HBV and the Microbiome-PubMed Database Literature Review.Infectious disease reports · 2026Review
- First-year dynamics of the plasma virome and cytokine profile in infants born to mothers with syphilis.Journal of translational medicine · 2026Article
- Short-term antiretroviral therapy may not correct the dysregulations of plasma virome and cytokines induced by HIV-1 infection.Virulence · 2025Article
- Biomarkers differentiating regression from progression among untreated cervical intraepithelial neoplasia grade 2 lesions.Journal of advanced research · 2025Review
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Assessment ofInternational journal of molecular sciences · 2025Article
- The human plasma anellome exhibits age- and sex-dependent patterns with links to cardiometabolic health in older adults.Frontiers in microbiology · 2025Article
- Large expansion of plasma commensal viruses is associated with SIV pathogenesis inScience advances · 2024Article
- Management of cytomegalovirus infection after liver transplantation.World journal of transplantation · 2024Review
- The plasma viral communities associate with clinical profiles in a large-scale haematological patients cohort.Microbiome · 2024Article
- Navigating Evolving Challenges in Blood Safety.Viruses · 2024Article
- Exploring the relationship between anellovirus load and clinical variables in hospitalized COVID-19 patients: Implications for immune activation and inflammation.IJID regions · 2023Article
- Exploring the Human Virome: Composition, Dynamics, and Implications for Health and Disease.Current microbiology · 2023Review
- Expansion ofViruses · 2023Article
- Article
- Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma.Scientific reports · 2023Article
- Altered vaginal eukaryotic virome is associated with different cervical disease status.Virologica Sinica · 2023Article
- Longitudinal anellome dynamics in the upper respiratory tract of children with acute respiratory tract infections.Virus evolution · 2023Article
- Plasma virome dynamics in chronic hepatitis B virus infected patients.Frontiers in microbiology · 2023Article
- Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of the microbiome in liver transplantation (LT) outcome has received a growing interest in the past decades. In contrast to bacteria, the role of endogenous viral communities, known as the virome, is poorly described. Here, we applied a viral metagenomic approach to study the dynamic evolution of circulating viruses in the plasma of LT recipients and its effect on the clinical course of patients.
methodsPatients chronically infected with hepatitis B virus (HBV) that received a LT due to endstage liver disease were included in this study. Longitudinal plasma samples were collected pre- and post-LT. Intact viral particles were isolated and sequenced on an Illumina HiSeq 2500 platform. Short read libraries were analysed with an in-house bioinformatics pipeline. Key endpoints were the dynamics of viral families and post-LT complications.
findingsThe initiation of immunosuppression induced a bloom of the Anelloviridae that dominated the post-LT plasma virome. A variety of post-LT complication were observed. Nephrotoxicity was reported in 38% of the patients and was associated with a high abundance of anelloviruses. Besides nephrotoxicity, 16 (67%) patients experienced flares of viral or bacterial infections in post-transplant follow-up. These flares were recognized by an increased burden of anelloviruses (p < 0.05). Interestingly, no mortality was observed in patients infected with human pegivirus.
interpretationThese findings suggest a diagnostic potential for the Anelloviridae family in post-LT complications. Furthermore, the impact of human pegivirus infection on post-transplant survival should be further investigated.
fundingThis trial was supported by Gilead Sciences grant number BE-2017-000133.
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