Evidence map›Paper›PMID 32979784›Full record

ArticleParkinsonism & related disorders2020

Multimodal assessment of nigrosomal degeneration in Parkinson's disease.

Jason Langley, Daniel E Huddleston, Bruce Crosson, David D Song, Stewart A Factor, Xiaoping Hu

Abstract read
In one paragraph

Article in Parkinsonism & related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Locus coeruleus degeneration is associated with orthostatic hypotension in Parkinson's disease and multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Application of Neuromelanin MR Imaging in Parkinson Disease.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jason LangleyCenter for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, USA.
Daniel E HuddlestonDepartment of Neurology, Emory University, Atlanta, GA, USA.
Bruce CrossonDepartment of Neurology, Emory University, Atlanta, GA, USA; Department of Veterans Affairs Center for Visual and Neurocognitive Rehabilitation, Atlanta Veterans Affairs Medical Center, Decatur, GA, USA; Department of Psychology, Georgia State University, Atlanta, GA, USA.
David D SongDepartment of Neurosciences, University of California, Riverside, Riverside, CA, USA.
Stewart A FactorDepartment of Neurology, Emory University, Atlanta, GA, USA.
Xiaoping HuCenter for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, USA; Department of Bioengineering, University of California, Riverside, Riverside, CA, USA. Electronic address: xhu@engr.ucr.edu.

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2005 to 2019
$25.7M
Neuroprotective Treatment Trial Planning in REM Sleep Behavior DisorderR34AG056639 · NIA · WASHINGTON UNIVERSITY · PI BOEVE, BRADLEY F, JU, YO-EL S · 2018 to 2019
$1.2M
MRI Signatures of Neuromelanin and Iron Pathology in ParkinsonismK23NS105944 · NINDS · EMORY UNIVERSITY · PI HUDDLESTON, DANIEL · 2018 to 2022
$963k
Upgrading a 3T MRI Scanner for Shared Research at Emory UniversityS10OD016413 · OD · EMORY UNIVERSITY · PI HU, XIAOPING P · 2013 to 2013
$495k
NIA NIH HHS P50 AG025688NIA NIH HHS R34 AG056639NIH HHS S10 OD016413NINDS NIH HHS K23 NS105944
6 · The paper itself

Abstract

backgroundApproximately forty percent of all dopaminergic neurons in SNpc are located in five dense neuronal clusters, named nigrosomes. T

methodsNeuromelanin-sensitive and multi-echo gradient echo imaging data were obtained. R

resultsTwo bilateral clusters emerged from the qVBM analysis. These clusters showed reduced neuromelanin-sensitive contrast and increased mean R

conclusionqVBM cluster-1 shows reduced neuromelanin-sensitive contrast and is in a similar spatial position as nigrosome-1. This region likely corresponds to nigrosome-1 while the second cluster may correspond to nigrosome-2.

Indexed as

Magnetic Resonance ImagingNeuroimagingAgedAtlases as TopicDopaminergic NeuronsFemaleHumansMaleMelaninsMiddle AgedParkinson DiseaseSubstantia NigraMelaninsneuromelaninIronNeuromelaninNigrosome-1Parkinson's diseaseSubstantia nigra

Identifiers

PMID32979784
PMCPMC7738361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.