Evidence map›Paper›PMID 32979746›Full record

ArticleResearch in veterinary science2020

Research methodology for in vivo measurements of resting energy expenditure, daily body temperature, metabolic heat and non-viral tissue-specific gene therapy in baboons.

Patrice A Frost, Shuyuan Chen, Ernesto Rodriguez-Ayala, Hugo A Laviada-Molina, Zoila Vaquera, Janeth F Gaytan-Saucedo, Wen-Hong Li, Karin Haack, Paul A Grayburn, Ken Sayers and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in veterinary science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Patrice A FrostPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Shuyuan ChenDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, United States of America.
Ernesto Rodriguez-AyalaCentro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac Norte, Naucalpan de Juárez 52786, Mexico.
Hugo A Laviada-MolinaEscuela de Ciencias de la Salud, Universidad Marista de Mérida, Mérida 97300, Yucatán, Mexico.
Zoila VaqueraPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Janeth F Gaytan-SaucedoPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Wen-Hong LiDepartments of Cell Biology and of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235, United States of America.
Karin HaackPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Paul A GrayburnDivision of Cardiology, Department of Internal Medicine, Baylor University Medical Center and the Baylor Scott and White Heart and Vascular Hospital, Dallas, TX, United States of America.
Ken SayersPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA.
Raul A BastarracheaPopulation Health Program, Texas Biomedical Research Institute, Southwest National Primate Research Center (SNPRC), San Antonio, TX 78227-0549, USA. Electronic address: raul@txbiomed.org.
Texas Biomedical Research Institute · USThe University of Texas Southwestern Medical Center · USBaylor Medical Center at Garland · USUniversidad Anáhuac · MXUniversidad Marista de Mérida · MX

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Defining the Normal Range of Postprandial Metabolic Risk: Multi-omic and multi-tissue Analysis after a Mixed MealR56DK114703 · NIDDK · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BASTARRACHEA, RAUL A, KENT, JOHN W · 2017 to 2018
$545k
NIDDK NIH HHS R56 DK114703NIH HHS P51 OD011133
6 · The paper itself

Abstract

A large number of studies have shown that the baboon is one of the most commonly used non-human primate (NHP) research model for the study of immunometabolic complex traits such as type 2 diabetes (T2D), insulin resistance (IR), adipose tissue dysfunction (ATD), dyslipidemia, obesity (OB) and cardiovascular disease (CVD). This paper reports on innovative technologies and advanced research strategies for energetics and translational medicine with this NHP model. This includes the following: measuring resting energy expenditure (REE) with the mobile indirect calorimeter Breezing®; monitoring daily body temperature using subcutaneously implanted data loggers; quantifying metabolic heat with veterinary infrared thermography (IRT) imaging, and non-viral non-invasive, tissue-specific ultrasound-targeted microbubble destruction (UTMD) gene-based therapy. These methods are of broad utility; for example, they may facilitate the engineering of ectopic overexpression of brown adipose tissue (BAT) mUCP-1 via UTMD-gene therapy into baboon SKM to achieve weight loss, hypophagia and immunometabolic improvement. These methods will be valuable to basic and translational research, and human clinical trials, in the areas of metabolism, cardiovascular health, and immunometabolic and infectious diseases.

Indexed as

Body TemperatureEnergy MetabolismResearch DesignAnimalsDisease Models, AnimalGenetic TherapyMonitoring, PhysiologicPapioThermographyBaboonsData loggersGene therapyIndirect calorimetryMetabolic heatUTMDVeterinary infrared thermography

Identifiers

PMID32979746
PMCPMC8179256
OpenAlexW3088598510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.