ReviewAgeing research reviews2020
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging.
Review in Ageing research reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Is Stress an Overlooked Risk Factor for Dementia? A Systematic Review from a Lifespan Developmental Perspective.Prevention science : the official journal of the Society for Prevention Research · 2023Pooled it
- Trial
- Psychedelics and the 'inner healer': Myth or mechanism?Journal of psychopharmacology (Oxford, England) · 2024Trial
- Prepandemic Physical Activity and Risk of COVID-19 Diagnosis and Hospitalization in Older Adults.JAMA network open · 2024Trial
- Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.Nutrients · 2021Trial
- Relationship between objective sleep efficiency and psychological distress in middle-aged and older Japanese: Results by work in the Shika study.BMC psychology · 2026Article
- Gender affirmation among transgender and gender-diverse people in middle age and late life: a scoping review.The Gerontologist · 2026Article
- Homebound status and glycemic control among older adults: results from a national survey.GeroScience · 2026Article
- Childhood socioeconomic status and changes in biological aging across mid-to-later life.Social science & medicine (1982) · 2026Article
- Leveraging mitochondrial stress to improve healthy aging.Sports medicine and health science · 2026Review
- Translation, Cultural Adaptation, and Psychometric Validity of the Greek Version of Questionnaires: The World Health Organization Quality of Life: OLD (WHOQOL-OLD), Older People's Quality of Life Questionnaire (OPQOL-35).Advances in experimental medicine and biology · 2026Article
- Developing and Evaluating the Comprehensive Hierarchical Eustress Review (CHER).Journal of happiness studies · 2026Article
- Article
- Impact of psychosocial stress in early life on pace of aging in young adulthood.Clinical epigenetics · 2025Article
- Article
- Health and aging trajectories: shared and competing risks and resiliencies for chronic diseases associated with aging. A NIH-wide workshop.Frontiers in public health · 2025Article
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress.Scientific reports · 2024Observational
- A randomized controlled clinical trial of a Wim Hof Method intervention in women with high depressive symptoms.Comprehensive psychoneuroendocrinology · 2024Article
- Is age more than a number? Accounting for adult development and aging in the study of psychoneuroimmunology, stress, and health.Comprehensive psychoneuroendocrinology · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by focusing on slowing the biological aging process for extended healthspan earlier in life. Remarkable progress has led this field toward animal trials and the next challenge lies with translation to humans. There is an emerging number of small human trials that can take advantage of new models integrating behavioral and social factors. Understanding dynamic aging mechanisms, given the powerful social determinants of aging (Crimmins, 2020) and human variability and environmental contexts (Moffitt, 2020), will be critical. Behavioral and social factors are intrinsic to aging. Toxic stressors broadly defined can lead to stress-acceleration of aging, either directly impacting aging processes or by shaping poor behavioral health, and underlie the socioeconomic disparities of aging. In contrast, hormetic stressors, acute intermittent stressors of moderate intensity, can produce stress resilience, the ability for quick recovery and possibly rejuvenation of cells and tissues. Although health research usually examines static biomarkers, aging is reflected in dynamic ability to recover from challenges pointing to new interventions and targets for examining mechanisms. A fuller model incorporating stress resilience provides innovative biobehavioral interventions, both for bolstering response to challenges, such as COVID-19, and for improving healthspan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.