Evidence map›Paper›PMID 32979497›Full record

ArticleNitric oxide : biology and chemistry2020

Nitric oxide synthase inhibition with N(G)-monomethyl-l-arginine: Determining the window of effect in the human vasculature.

Andrew C Kithas, Ryan M Broxterman, Joel D Trinity, Jayson R Gifford, Oh Sung Kwon, Jay R Hydren, Ashley D Nelson, Jacob E Jessop, Amber D Bledsoe, David E Morgan and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nitric oxide : biology and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The role of the endothelium in the hyperemic response to passive leg movement: looking beyond nitric oxide.American journal of physiology. Heart and circulatory physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Andrew C KithasDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Ryan M BroxtermanDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA; Geriatric Research, Education, and Clinical Center, Salt Lake City, VAMC, UT, USA.
Joel D TrinityDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA; Department of Nutrition and Integrative Physiology, USA; Geriatric Research, Education, and Clinical Center, Salt Lake City, VAMC, UT, USA.
Jayson R GiffordDepartment of Exercise Sciences, Brigham Young University, Provo, UT, USA.
Oh Sung KwonDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.
Jay R HydrenDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA; Department of Nutrition and Integrative Physiology, USA; Geriatric Research, Education, and Clinical Center, Salt Lake City, VAMC, UT, USA.
Ashley D NelsonDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Jacob E JessopDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Amber D BledsoeDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
David E MorganDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Russell S RichardsonDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA; Department of Nutrition and Integrative Physiology, USA; Geriatric Research, Education, and Clinical Center, Salt Lake City, VAMC, UT, USA. Electronic address: R.Richardson@hsc.utah.edu.
University of Utah · USBrigham Young University · USUniversity of Connecticut · US

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Tissue Imaging, Biochemistry and MorphologyP01HL091830 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHARDSON, RUSSELL S. · 2009 to 2013
$10.1M
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseR01HL142603 · NHLBI · UNIVERSITY OF UTAH · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
$2.9M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Exercise and Cognitive Function in Alzheimers Disease Progression: Role of the Vascular EndotheliumR56AG057584 · NIA · UNIVERSITY OF UTAH · PI RICHARDSON, RUSSELL S. · 2018 to 2018
$658k
Rehabilitation for Hypertension: Exercise and Skeletal Muscle Afferent FeedbackI21RX001433 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2014 to 2015
–
Vascular Endothelial Function: A Potential Therapeutic Target in Alzheimer's DiseaseI01RX002323 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2017 to 2024
–
Passive limb movement: A tool to assess vascular health and guide rehabilitationI01RX001697 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2015 to 2018
–
Oxidative stress links aging, activity, and mobility limitationI01RX000182 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI RICHARDSON, RUSSELL S. · 2012 to 2014
–
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during DisuseI01CX001999 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI TRINITY, JOEL DOUGLAS · 2019 to 2023
–
CSRD VA I01 CX001999NHLBI NIH HHS P01 HL091830NHLBI NIH HHS R01 HL142603NHLBI NIH HHS T32 HL007576NHLBI NIH HHS T32 HL139451NIA NIH HHS R56 AG057584RRD VA I01 RX000182RRD VA I01 RX001697RRD VA I01 RX002323RRD VA I21 RX001433
6 · The paper itself

Abstract

Nitric oxide synthase (NOS) inhibition with N(G)-monomethyl-l-arginine (L-NMMA) is often used to assess the role of NO in human cardiovascular function. However, the window of effect for L-NMMA on human vascular function is unknown, which is critical for designing and interpreting human-based studies. This study utilized the passive leg movement (PLM) assessment of vascular function, which is predominantly NO-mediated, in 7 young male subjects under control conditions, immediately following intra-arterial L-NMMA infusion (0.24 mg⋅dl

Indexed as

AdultEnzyme InhibitorsFemoral ArteryHemodynamicsHumansLegMaleNitric OxideNitric Oxide Synthaseomega-N-MethylarginineRegional Blood FlowTime FactorsYoung AdultEnzyme InhibitorsNitric OxideNitric Oxide Synthaseomega-N-MethylarginineL-NMMANO bioavailabilityNOSVascular functionVasodilation

Identifiers

PMID32979497
PMCPMC7667496
OpenAlexW3088028607

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.