Evidence map›Paper›PMID 32979407›Full record

ArticleJournal of virological methods2021

Determination of SARS-CoV-2 antibodies with assays from Diasorin, Roche and IDvet.

Alexander Krüttgen, Christian G Cornelissen, Michael Dreher, Mathias W Hornef, Matthias Imöhl, Michael Kleines

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of virological methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

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  19. Evaluation of the AMP SARS-CoV-2 rapid antigen test in a hospital setting.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexander KrüttgenLaboratory Diagnostic Center, University Hospital RWTH Aachen, Germany.
Christian G CornelissenDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Germany.
Michael DreherDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Germany.
Mathias W HornefInstitute of Medical Microbiology, University Hospital RWTH Aachen, Germany.
Matthias ImöhlLaboratory Diagnostic Center, University Hospital RWTH Aachen, Germany.
Michael KleinesLaboratory Diagnostic Center, University Hospital RWTH Aachen, Germany. Electronic address: mkleines@ukaachen.de.
RWTH Aachen University · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an ongoing need for highly reliable serological assays to detect individuals with past SARS-CoV-2 infection. Using 75 sera from patients tested positive or negative by SARS-CoV-2 PCR, we investigated the sensitivity and specificity of the Liaison SARS-CoV-2 S1/S2 IgG assay (DiaSorin), the Elecsys Anti-SARS-CoV-2 assay (Roche), and the ID Screen SARS-CoV-2-N IgG indirect kit (IDVet). We determined a sensitivity of 95.5 %, 95.5 %, and 100 % and a specificity of 90.5 %, 96.2 %, and 92.5 % for the DiaSorin assay, the Roche assay, and the IDVet assay, respectively. We conclude that serologic assays combining very high sensitivity and specificity are still not commercially available for SARS-CoV-2. For maximizing sensitivity and specificity of SARS-CoV-2 serological diagnostics, the combination of two assays may be helpful.

Indexed as

Antibodies, ViralCOVID-19COVID-19 Serological TestingHumansImmunoassayImmunoglobulin GSARS-CoV-2Sensitivity and SpecificityAntibodies, ViralImmunoglobulin GCOVID-19ELISASARS-CoV-2Serology

Identifiers

PMID32979407
PMCPMC7510775
OpenAlexW3087322729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.