Trial reportThe Journal of pediatrics2021
Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial.
Abstract readRandomized Controlled Trial
In one paragraph
Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants.The Cochrane database of systematic reviews · 2025Pooled it
- Patent Ductus Arteriosus and Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Bayesian Meta-Analysis.JAMA network open · 2023Pooled it
- Related Factors of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2020Pooled it
- Evaluation ofJournal of cardiovascular development and disease · 2026Article
- Respiratory severity score-guided postnatal systemic corticosteroid therapy for bronchopulmonary dysplasia in extremely preterm infants.Clinical and experimental pediatrics · 2025Article
- The pathogenesis of bronchopulmonary dysplasia: "It is never the heart, it is always the lung" - myth or maxim?Breathe (Sheffield, England) · 2025Review
- A Discourse on Percutaneous Closure of the Patent Ductus Arteriosus in Premature Neonates: Controversy, Remedy, or Paradox of Choice?CJC pediatric and congenital heart disease · 2025Review
- Prophylactic indomethacin and the risk of serious pulmonary hemorrhages in preterm infants less than 28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Patent ductus arteriosus and the association between lung ultrasound score and bronchopulmonary dysplasia: a secondary analysis of a prospective study.European journal of pediatrics · 2024Article
- Article
- Delineating morbidity patterns in preterm infants at near-term age using a data-driven approach.BMC pediatrics · 2024Article
- Plasma KL-6 as a Potential Biomarker for Bronchopulmonary Dysplasia in Preterm Infants.Critical care research and practice · 2024Article
- Article
- Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology.Journal of clinical medicine · 2023Review
- Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2023Article
- Effects of prophylactic indomethacin on morbidity and mortality in infants <25 weeks' gestation: a protocol driven intention to treat analysis.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Impact of patent ductus arteriosus shunt size and duration on risk of death or severe respiratory morbidity in preterm infants born in China.European journal of pediatrics · 2022Article
- Sex Differences in Patent Ductus Arteriosus Incidence and Response to Pharmacological Treatment in Preterm Infants: A Systematic Review, Meta-Analysis and Meta-Regression.Journal of personalized medicine · 2022Review
- Continuing interventions in a quality improvement bundle to reduce bronchopulmonary dysplasia.World journal of pediatrics : WJP · 2022Article
- An Update on Patent Ductus Arteriosus and What is Coming Next.Turkish archives of pediatrics · 2022Article
Corrections and comments
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Authors and funding
26 authors.
Ronald I ClymanDepartment of Pediatrics, University of California, San Francisco, CA; Cardiovascular Research Institute, University of California, San Francisco, CA.
Joseph KaempfDepartment of Pediatrics, Providence St Vincent Medical Center, Portland, OR.
Melissa LiebowitzDepartment of Pediatrics, University of California, San Francisco, CA.
Omer ErdeveDepartment of Pediatrics, Ankara University School of Medicine Children's Hospital, Ankara, Turkey.
Ali BulbulDepartment of Pediatrics, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
Stellan HåkanssonDepartment of Pediatrics, Umea University Hospital, Umea, Sweden.
Johanna LindqvistDepartment of Pediatrics, Umea University Hospital, Umea, Sweden.
Aijaz FarooqiDepartment of Pediatrics, Umea University Hospital, Umea, Sweden.
Anup KatheriaDepartment of Pediatrics, Sharp Mary Birch Hospital, San Diego, CA.
Jason SauberanDepartment of Pediatrics, Sharp Mary Birch Hospital, San Diego, CA.
Jaideep SinghDepartment of Pediatrics, University of Chicago, Chicago, IL.
Kelly NelsonDepartment of Pediatrics, University of Chicago, Chicago, IL.
Andrea WickremasingheDepartment of Pediatrics, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA.
Lawrence DongDepartment of Pediatrics, Kaiser Permanente Santa Clara Medical Center, Santa Clara, CA.
Denise C HassingerDepartment of Pediatrics, Morristown Medical Center, Morristown, NJ.
Susan W AucottDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD.
Madoka HayashiDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD.
Anne Marie HeuchanDepartment of Pediatrics, University of Glasgow, Royal Hospital for Sick Children, Glasgow, Scotland, UK.
William A CareyDepartment of Pediatrics, Mayo Clinic, Rochester, MN.
Matthew DerrickDepartment of Pediatrics, Northshore University Health System, Evanston, IL.
Erika FernandezDepartment of Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, CA.
Meera SankarDepartment of Pediatrics, Good Samaritan Hospital, San Jose, CA.
Tina LeoneDepartment of Pediatrics, Columbia University Medical Center, New York, NY.
Jorge PerezDepartment of Pediatrics, South Miami Hospital/Baptist Health South Florida, Miami, FL.
Arturo SerizeDepartment of Pediatrics, South Miami Hospital/Baptist Health South Florida, Miami, FL.
PDA-TOLERATE Trial Investigators
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MClinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MEngaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0MGenes contributing to patent ductus arteriosus susceptibility in preterm newbornsR01HL109199 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLYMAN, RONALD I · 2011 to 2014
$3.0MNCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001872NCATS NIH HHS UL1 TR001873NHLBI NIH HHS R01 HL109199
Abstract
In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required <10 days of intubation. However, in infants requiring intubation for ≥10 days, prolonged PDA exposure (≥11 days) was associated with an increased risk of moderate/severe BPD.
Indexed as
Respiration, ArtificialBronchopulmonary DysplasiaDuctus Arteriosus, PatentFemaleHumansInfant, NewbornIntubation, IntratrachealMaleProspective StudiesSeverity of Illness IndexTime Factorsbronchopulmonary dysplasiapatent ductus arteriosuspremature birth
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.