Evidence map›Paper›PMID 32979383›Full record

Trial reportThe Journal of pediatrics2021

Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.

J Lauren Ruoss, Catalina Bazacliu, Jordan T Russell, Diomel de la Cruz, Nan Li, Matthew J Gurka, Stephanie L Filipp, Richard A Polin, Eric W Triplett, Josef Neu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Risk assessment of early-onset sepsis in extremely preterm infants: implications for antibiotic stewardship.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
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  12. Review
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  18. Gut microbes
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

J Lauren RuossDivision of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL. Electronic address: lruoss@ufl.edu.
Catalina BazacliuDivision of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.
Jordan T RussellDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
Diomel de la CruzDivision of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.
Nan LiDivision of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.
Matthew J GurkaDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.
Stephanie L FilippDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, FL.
Richard A PolinDepartment of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY.
Eric W TriplettDepartment of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
Josef NeuDivision of Neonatology, Department of Pediatrics, University of Florida, Gainesville, FL.

Funding

UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Antibiotic Effects on the Developing Microbiome Metabolome and Morbidites in Preterm Neonates.R21HD088005 · NICHD · UNIVERSITY OF FLORIDA · PI NEU, JOSEF · 2017 to 2018
$419k
NCATS NIH HHS UL1 TR000064NICHD NIH HHS R21 HD088005
6 · The paper itself

Abstract

We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.

Indexed as

Streptococcus agalactiaeAge FactorsAnti-Bacterial AgentsFemaleHumansInfant, NewbornInfant, PrematureMalePilot ProjectsStreptococcal InfectionsAnti-Bacterial Agentsdysbiosisinfantsmicrobiomesepsis

Identifiers

PMID32979383
PMCPMC8958904

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.