Evidence map›Paper›PMID 32979312›Full record

ArticleNeuron2020

Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes.

Robert S Pulido, Roeben N Munji, Tamara C Chan, Clare R Quirk, Geoffrey A Weiner, Benjamin D Weger, Meghan J Rossi, Sara Elmsaouri, Mario Malfavon, Aaron Deng and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.

  1. Pooled it
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  19. Development of the blood-brain barrier.Development (Cambridge, England) · 2026
    Review
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Robert S PulidoDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: rspulido@ucsd.edu.
Roeben N MunjiDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Tamara C ChanDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Clare R QuirkNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Geoffrey A WeinerDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Benjamin D WegerInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Meghan J RossiDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Sara ElmsaouriDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Mario MalfavonDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Aaron DengDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Caterina P ProfaciDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Marie BlanchetteDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA.
Tongcheng QianDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Koji L ForemanDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Eric V ShustaDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.
Michael R GormanDepartment of Psychology and Center for Circadian Biology, University of California, San Diego, La Jolla, CA 92037, USA.
Frédéric GachonInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Stefan LeutgebNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA.
Richard DanemanDepartments of Neurosciences and Pharmacology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: rdaneman@ucsd.edu.
University of California San Diego · USUniversity of Wisconsin–Madison · USThe University of Queensland · AU

Funding

GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Blood Cells in Hemostasis and ThrombosisT32HL086344 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2008 to 2023
$4.4M
Regulation of blood-brain barrier formation and function by EHDsR01NS091281 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DANEMAN, RICHARD · 2015 to 2019
$1.9M
NHLBI NIH HHS T32 HL086344NIGMS NIH HHS T32 GM007752NINDS NIH HHS R01 NS091281
6 · The paper itself

Abstract

The blood vessels in the central nervous system (CNS) have a series of unique properties, termed the blood-brain barrier (BBB), which stringently regulate the entry of molecules into the brain, thus maintaining proper brain homeostasis. We sought to understand whether neuronal activity could regulate BBB properties. Using both chemogenetics and a volitional behavior paradigm, we identified a core set of brain endothelial genes whose expression is regulated by neuronal activity. In particular, neuronal activity regulates BBB efflux transporter expression and function, which is critical for excluding many small lipophilic molecules from the brain parenchyma. Furthermore, we found that neuronal activity regulates the expression of circadian clock genes within brain endothelial cells, which in turn mediate the activity-dependent control of BBB efflux transport. These results have important clinical implications for CNS drug delivery and clearance of CNS waste products, including Aβ, and for understanding how neuronal activity can modulate diurnal processes.

Indexed as

AnimalsBiological TransportBlood-Brain BarrierCircadian ClocksCircadian RhythmDesigner DrugsEndothelial CellsFemaleHomeostasisLocomotionMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsDesigner DrugsBlood-Brain BarrierCerebrovascular FunctionCircadian RhythmsEfflux transportNeuronal ActivityNeurovascular SignalingP-glycoproteinTranscriptomics

Identifiers

PMID32979312
PMCPMC7736535
OpenAlexW3087912656

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.