ArticleJournal of thrombosis and haemostasis : JTH2020
The relationship between DOAC levels and clinical outcomes: The measures tell the tale.
Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions.International journal of laboratory hematology · 2026Review
- Does the current apixaban dosing strategy adequately fit and ensure safety in Korean patients with atrial fibrillation?Blood research · 2025Article
- Real-world apixaban concentration in Korean patients with atrial fibrillation.Blood research · 2025Article
- DOACs: role of anti-Xa and drug level monitoring.Hematology. American Society of Hematology. Education Program · 2024Review
- Handling delayed or missed direct oral anticoagulant doses: model-informed individual remedial dosing.Blood advances · 2024Article
- Interactions Between Direct Oral Anticoagulants (DOACs) and Antiseizure Medications: Potential Implications on DOAC Treatment.CNS drugs · 2023Article
- Physical activity for children with deep vein thrombosis and pulmonary embolism on anticoagulation: a scoping review.Research and practice in thrombosis and haemostasis · 2023Article
- The myths behind DOAC measurement: Analyses of prescribing information from different regulatory bodies and a call for harmonization.Journal of thrombosis and haemostasis : JTH · 2022Article
- Pharmacokinetics of Direct Oral Anticoagulants in Emergency Situations: Results of the Prospective Observational RADOA-Registry.Thrombosis and haemostasis · 2022Observational
- Predictors of use of direct oral anticoagulants in patients with venous thromboembolism: Findings from the Registro Informatizado Enfermedad Tromboembólica registry.Frontiers in medicine · 2022Article
- Inter- and intra-individual concentrations of direct oral anticoagulants: The KIDOAC study.Journal of thrombosis and haemostasis : JTH · 2022Article
- The Clinical Significance of Drug-Food Interactions of Direct Oral Anticoagulants.International journal of molecular sciences · 2021Review
- The relationship between DOAC levels and clinical outcomes: The measures tell the tale.Journal of thrombosis and haemostasis : JTH · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Direct oral anticoagulants (DOACs) are increasingly used for treatment and prevention of thromboembolic diseases, used in fixed dose regimens. Although their safety and efficacy profiles are considered optimal, clinical events still occur. Given that anticoagulation treatment is a delicate balance between clotting and bleeding, it is possible that an optimal target spot exists where the effect of anticoagulation achieves both the lowest possible risk of bleeding and thrombosis. Other currently available anticoagulants (ie, vitamin K antagonists and heparins) provide important clues for this. If such a target spot exists, tailored DOAC therapy may further benefit patients. This opinion article summarizes the current available evidence that suggests that such a tailored strategy could work. It also describes research suggestions for conducting studies in patient populations such as patients with extremes of body weight or impaired kidney function to evaluate whether tailored treatment with DOACs could lead to better patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.