ArticleJournal of thrombosis and haemostasis : JTH2020
Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients.
Article in Journal of thrombosis and haemostasis : JTH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Neonatal critical illness is associated with pancytopenia development in childhood.medRxiv : the preprint server for health sciences · 2026Article
- Inflammation, anemia, and vitamin D levels associate with infant thrombocytosis risk.Research and practice in thrombosis and haemostasis · 2026Article
- [Advances in the diagnosis and treatment of thrombocytosis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Etiology and clinical course of severe and extreme thrombocytosis in children: a retrospective single-center study.European journal of pediatrics · 2024Article
- [Etiologies of extreme thrombocytosis in children: a retrospective study].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2023Article
- High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients.Platelets · 2022Article
- Pathophysiology, classification, and complications of common asymptomatic thrombocytosis in newborn infants.Clinical and experimental pediatrics · 2022Article
- Essential Thrombocythemia in Children and Adolescents.Cancers · 2021Review
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExtreme thrombocytosis (EXT, platelet count > 1000 × 10
objectivesOur objectives were to determine etiologies and sequelae of EXT in a hospitalized general pediatric patient population. PATIENTS AND
methodsWe retrospectively analyzed EXT cases from a single-center pediatric cohort of ~80 000 patients over 8 years.
resultsVirtually all cases (99.8%) were secondary in nature, and most were multifactorial. Many cases of EXT occurred in children under 2 years old (47%) and/or during critical illness (55%). No thrombotic or bleeding events directly resulted from EXT, confirming a paucity of clinical complications associated with EXT in pediatric patients. There were indications that neonatal hematopoiesis and individual genetic variation influenced some cases, in addition to certain diagnoses (eg, sickle cell anemia) and clinical contexts (eg, asplenia).
conclusionOur findings confirm that thrombotic events related to EXT are rare in pediatric patients, which can inform the use of empiric anti-platelet therapy.
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