ReviewFEBS letters2020
Structural and functional diversity calls for a new classification of ABC transporters.
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Review in FEBS letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers.
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165citing papers in PubMed
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165 citing papers in PubMed.
- Recognition and mechanism of M. tuberculosis cell wall galactan transport.Nature communications · 2026Article
- Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition.Science advances · 2026Article
- ATP-driven conformational dynamics reveal hidden intermediates in a heterodimeric ABC transporter.eLife · 2026Article
- Cryo-electron microscopy structure of a zinc uptake ABC transporter.Structure (London, England : 1993) · 2026Article
- The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA.Chembiochem : a European journal of chemical biology · 2026Article
- TMcin RiPP biosynthesis in the cellular membrane.bioRxiv : the preprint server for biology · 2026Article
- Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance.International journal of molecular sciences · 2026Review
- Structural insights into Arabidopsis thaliana CTS-mediated fatty acid and hormone metabolism.Nature communications · 2026Article
- Cryo-EM structures of human ABCB7 reveal the molecular basis of mitochondrial matrix heme export.Communications biology · 2026Article
- The Arsenal of Aromatic Degrading Bacteria: How They Sense, Chase, Adapt and Destroy Environmental Pollutants.Microbial biotechnology · 2026Review
- Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters.Nature communications · 2026Article
- ABCG2 Genetic Variability in Drug Exposure and Toxicity: Implications for Clinical Practice.Toxics · 2026Review
- Article
- Characterization of the YCjN ABC Transporter in Escherichia coli: Role in Maltose and Ethidium Bromide Transport.Molecular biotechnology · 2026Article
- Single-molecule dynamics reveal ATP binding alone powers substrate translocation by an ABC transporter.Nature communications · 2026Article
- A dual sensor regulates P-glycoprotein's structural plasticity.bioRxiv : the preprint server for biology · 2026Article
- Predictive modelling of the COMATOSE transporter reveals a conserved ligand binding pocket for acyl-CoAs.Scientific reports · 2026Article
- Braess' Paradox in Enzyme Kinetics: Asymmetry from Population Balance without Direct Cooperativity.Journal of chemical theory and computation · 2026Article
- Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics.Structure (London, England : 1993) · 2026Article
- Molecular mechanism of substrate transport by human peroxisomal ABCD3.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
105 more citing papers are in PubMed but not listed here.
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Authors and funding
43 authors.
Christoph ThomasInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.ORCID 0000-0001-7441-1089
Stephen G AllerDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, AL, USA.ORCID 0000-0003-0379-5534
Konstantinos BeisDepartment of Life Sciences, Imperial College London, London South Kensington, UK.ORCID 0000-0001-5727-4721
Elisabeth P CarpenterStructural Genomics Consortium, University of Oxford, UK.
Geoffrey ChangSkaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Lei ChenState Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China.
Elie DassaInstitut Pasteur, Paris Cedex 15, France.
Michael DeanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.ORCID 0000-0003-2234-0631
Franck Duong Van HoaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Damian EkiertDepartment of Cell Biology and Department of Microbiology, New York University School of Medicine, NY, USA.
Robert FordFaculty of Biology, Medicine and Health, The University of Manchester, UK.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Xin GongDepartment of Biology, Southern University of Science and Technology, Shenzhen, China.
I Barry HollandInstitute for Integrative Biology of the Cell (I2BC), Université Paris-Sud, Orsay, France.
Yihua HuangNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Daniel K KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Hiroaki KatoInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan.
Vassilis KoronakisDepartment of Pathology, University of Cambridge, UK.
Christopher M KothStructural Biology, Genentech Inc., South San Francisco, CA, USA.
Youngsook LeeDivision of Integrative Bioscience and Biotechnology, POSTECH, Pohang, Korea.
Oded LewinsonDepartment of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
Roland LillInstitut für Zytobiologie, Philipps-Universität Marburg, Germany.ORCID 0000-0002-8345-6518
Enrico MartinoiaDepartment of Plant and Microbial Biology, University Zurich, Switzerland.
Satoshi MurakamiDepartment of Life Science, Tokyo Institute of Technology, Yokohama, Japan.ORCID 0000-0001-5553-7663
Heather W PinkettDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-1102-1515
Bert PoolmanDepartment of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.ORCID 0000-0002-1455-531X
Daniel RosenbaumDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Balazs SarkadiInstitute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary.
Lutz SchmittInstitute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-1167-9819
Erwin SchneiderDepartment of Biology/Microbial Physiology, Humboldt-University of Berlin, Germany.
Yigong ShiInstitute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, China.
Show-Ling ShyngDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
Dirk J SlotboomDepartment of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.ORCID 0000-0002-5804-9689
Emad TajkhorshidDepartment of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.
D Peter TielemanDepartment of Biological Sciences and Centre for Molecular Simulation, University of Calgary, AB, Canada.ORCID 0000-0001-5507-0688
Kazumitsu UedaInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), KUIAS, Kyoto University, Japan.ORCID 0000-0003-2980-6078
András VáradiInstitute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary.ORCID 0000-0002-2722-7120
Po-Chao WenDepartment of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.ORCID 0000-0002-6049-6904
Nieng YanDepartment of Molecular Biology, Princeton University, NJ, USA.
Peng ZhangNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Hongjin ZhengDepartment of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jochen ZimmerMolecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Robert TampéInstitute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.ORCID 0000-0002-0403-2160
Funding
Structural Basis of KATP Channel GatingR01DK066485 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHYNG, SHOW-LING · 2006 to 2024
$5.8MSupplementR01GM140584 · NIGMS · NORTHWESTERN UNIVERSITY · PI PINKETT, HEATHER WENDY · 2020 to 2024
$1.9MMechanistic studies of prokaryotic and eukaryotic nitrate/nitrite transportR01GM126626 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ZHENG, HONGJIN · 2018 to 2022
$1.7MMedical Research Council MR/N000994/1Medical Research Council MR/N020103/1NIDDK NIH HHS R01 DK066485NIGMS NIH HHS R01 GM126626NIGMS NIH HHS R01 GM140584Wellcome TrustWellcome Trust 101828/Z/13/Z
Abstract
Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.
Indexed as
Protein DomainsATP-Binding Cassette TransportersProtein FoldingATP-Binding Cassette TransportersABC transportersATPasescryo-EMmembrane proteinsmolecular machinesphylogenyprimary active transporterssequence alignmentstructural biologyX-ray crystallography
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