Evidence map›Paper›PMID 32978860›Full record

ArticleEuropean journal of neurology2021

Multiple sclerosis and COVID-19: How many are at risk?

Gabriel Bsteh, Christina Bitschnau, Harald Hegen, Michael Auer, Franziska Di Pauli, Paulus Rommer, Florian Deisenhammer, Thomas Berger

Abstract readCase Reports
In one paragraph

Article in European journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective Study from a Single Center in Kosovo.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Humoral immune response after COVID-19 in multiple sclerosis: A nation-wide Austrian study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Multiple sclerosis and COVID-19: How many are at risk?European journal of neurology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriel BstehDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-0825-0851
Christina BitschnauDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Harald HegenDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-2833-6337
Michael AuerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Franziska Di PauliDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Paulus RommerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-5209-6647
Florian DeisenhammerDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Thomas BergerDepartment of Neurology, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe coronavirus disease 2019 (COVID-19) pandemic challenges neurologists in counseling multiple sclerosis (MS) patients with respect to their risk for and by severe acute respiratory syndrome coronavirus 2 and in guiding disease-modifying treatment (DMT). The objective was to determine the frequency and distribution of currently known risk factors for COVID-19 mortality in an MS population.

methodsMultiple sclerosis patients with at least one complete case report between January 1, 2015 and December 31, 2019 from the Innsbruck MS database were cross-sectionally included. Frequencies of currently estimated COVID-19 mortality risk factors were analyzed, and the cumulative risk was calculated by a recently developed score. For every risk group, the proportions of patients under DMT and immunosuppressive treatment were determined.

resultsOf 1931 MS patients, 63.4% had low risk of COVID-19 mortality, 26% had mild risk, 8.8% had a moderate risk, whereas a combined 0.9% had high or very high risk of COVID-19 mortality. Of the patients at high or very high risk, only one patient received DMT and none had an immunosuppressive therapy.

conclusionsIn a population-based MS cohort, the proportion of patients at high risk of COVID-19 mortality is below 1%. Importantly, the vast majority of these MS patients did not receive any DMT.

Indexed as

COVID-19Multiple SclerosisHumansImmunosuppressive AgentsPandemicsSARS-CoV-2Immunosuppressive AgentscomorbiditiesCOVID-19multiple sclerosisriskSARS-CoV-2

Identifiers

PMID32978860
PMCPMC7537184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.