ArticleJournal of neurochemistry2021
Olfactory bulb-targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice.
Article in Journal of neurochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
- Olfactory bulbectomy-induced impairment of lipid utilization leads to abnormal glucose metabolism in mice.PloS one · 2025Article
- Ion Channels in Odor Information Processing of Neural Circuits of the Vertebrate Olfactory Bulb.International journal of molecular sciences · 2024Review
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.Molecular metabolism · 2024Article
- Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice.Acta pharmacologica Sinica · 2024Article
- Obesity- and diet-induced plasticity in systems that control eating and energy balance.Obesity (Silver Spring, Md.) · 2024Review
- Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro.Scientific reports · 2023Article
- Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.PloS one · 2023Article
- GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cellFrontiers in molecular neuroscience · 2023Article
- Food odor perception promotes systemic lipid utilization.Nature metabolism · 2022Article
- Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice.The Journal of physiology · 2022Article
- GLP-1 Suppresses Feeding Behaviors and Modulates Neuronal Electrophysiological Properties in Multiple Brain Regions.Frontiers in molecular neuroscience · 2021Review
- Optimization ofFrontiers in pharmacology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
The olfactory system is a driver of feeding behavior, whereby olfactory acuity is modulated by the metabolic state of the individual. The excitability of the major output neurons of the olfactory bulb (OB) can be modulated through targeting a voltage-dependent potassium channel, Kv1.3, which responds to changes in metabolic factors such as insulin, glucose, and glucagon-like peptide-1. Because gene-targeted deletion or inhibition of Kv1.3 in the periphery has been found to increase energy metabolism and decrease body weight, we hypothesized that inhibition of Kv1.3 selectively in the OB could enhance excitability of the output neurons to evoke changes in energy homeostasis. We thereby employed metal-histidine coordination to self-assemble the Kv1.3 inhibitor margatoxin (MgTx) to fluorescent quantum dots (QDMgTx) as a means to label cells in vivo and test changes in neuronal excitability and metabolism when delivered to the OB. Using patch-clamp electrophysiology to measure Kv1.3 properties in heterologously expressed cells and native mitral cells in OB slices, we found that QDMgTx had a fast rate of inhibition, but with a reduced IC
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