ArticleSleep2021
Associations between adolescent sleep deficiency and prescription opioid misuse in adulthood.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Sleep Health Among Adults in Outpatient Opioid Use Disorder Treatment: A Systematic Review.Journal of psychosocial nursing and mental health services · 2024Pooled it
- Prescription Opioid Misuse Among High School Athletes During the Opioid Prescribing Limit Law Era: YRBSS 2017-2023.Healthcare (Basel, Switzerland) · 2026Article
- The Adolescent Surgery Experience (ASE): a survey-based prospective cohort study to measure risk factors for persistent opioid use.BJA open · 2025Article
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- Sleep quality and associated factors among people who inject drugs in Iran: a nationwide survey using respondent-driven sampling.BMC public health · 2024Article
- Ecological momentary assessment of sleep, pain, and opioid use among adolescents following surgery.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Promoting sleep health to mitigate the risk of nonmedical opioid use and opioid-related adverse events.Sleep · 2023Article
- Disparities in sleep duration among American children: effects of race and ethnicity, income, age, and sex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Sex Specific Sleep Parameters Among People With Substance Use Disorder.Frontiers in psychiatry · 2022Article
- Mind-body approaches for reducing the need for post-operative opioids: Evidence and opportunities.Journal of clinical anesthesia and intensive care · 2022Article
- Associations between insufficient sleep and prescription opioid misuse among high school students in the United States.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- At the intersection of sleep deficiency and opioid use: mechanisms and therapeutic opportunities.Translational research : the journal of laboratory and clinical medicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesThe main aim of this study was to estimate the association between sleep deficiency in adolescence and subsequent prescription opioid misuse in adulthood using United States nationally representative longitudinal data.
methodsSelf-reported data captured in the National Longitudinal Study of Adolescent to Adult Health at baseline (Wave 1; mean age = 16 years) and 12 year follow-up (Wave 4; mean age = 29 years). Participants (n = 12,213) reported on four measures of sleep during adolescence (Wave 1) and on lifetime prescription opioid misuse during adulthood (Wave 4). Associations between adolescent sleep and adult opioid misuse were estimated using multivariate logistic regression analysis controlling for sociodemographics, chronic pain, mental health, childhood adverse events, and a history of substance use.
resultsDuring adolescence, 59.2% of participants reported sleep deficiency. Prospectively, adolescents reporting not getting enough sleep, chronic unrestful sleep, and insomnia were associated with an increased risk for prescription opioid misuse (adjusted odds ratios [OR] = 1.2, p < 0.005 for all three variables). Short sleep duration was not associated with opioid misuse.
conclusionThis is the first study to longitudinally link sleep deficiency as an independent risk factor for the development of prescription opioid misuse. Sleep deficiency could be a driver of the opioid crisis affecting young people in the United States. Future studies should determine whether early and targeted sleep interventions may decrease risk for opioid misuse in high-risk patients prescribed opioids for pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.