Evidence map›Paper›PMID 32978526›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2021

Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants.

Courtney D Thornburg, Stephen W Erickson, Grier P Page, Erin A S Clark, Margaret M DeAngelis, M Elizabeth Hartnett, Ricki F Goldstein, John M Dagle, Jeffrey C Murray, Brenda B Poindexter and 3 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Courtney D ThornburgDepartment of Pediatrics, Duke University, Durham, NC, USA. cthornburg@rchsd.org.ORCID http://orcid.org/0000-0002-5665-8958
Stephen W EricksonSocial, Statistical and Environmental Sciences, RTI, Research Triangle Park, NC, USA.
Grier P PageDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-2582-3786
Erin A S ClarkDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
Margaret M DeAngelisDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
M Elizabeth HartnettDepartment of Pediatrics, University of Kentucky, Lexington, KY, USA.
Ricki F GoldsteinDepartment of Pediatrics, Duke University, Durham, NC, USA.
John M DagleDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Brenda B PoindexterDepartment of Pediatrics, University of Indiana, Indianapolis, IN, USA.
Abhik DasHemophilia and Thrombosis Treatment Center, Rady Children's Hospital San Diego, San Diego, CA, USA.
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
University of Utah · USDuke University · USUniversity of Iowa · USUniversity of Kentucky · USIndiana University – Purdue University Indianapolis · USRady Children's Hospital-San Diego · USTriangle · US

Funding

WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI HEUBI, JAMES E. · 1994 to 2009
$20.6M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7M
Early Check: A Collaborative Innovation to Facilitate Pre-Symptomatic Clinical Trials in NewbornsU01TR001792 · NCATS · RESEARCH TRIANGLE INSTITUTE · PI BAILEY, DONALD B, COTTEN, CHARLES MICHAEL · 2016 to 2020
$7.8M
Endothelial Transmigration in Neovascular Age-related Macular DegenerationR01EY017011 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARTNETT, MARY ELIZABETH RUTH · 2007 to 2025
$7.7M
Mechanisms of Angiogenesis of Retinopathy of PrematurityR01EY015130 · NEI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mary Elizabeth Ruth Hartnett · 2005 to 2026
$7.6M
USE OF OXANDROLONE TO IMPROVE FUNCTION IN CHRONIC SCIM01RR016587 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FLOREZ, HERMES · 2002 to 2005
$6.8M
ZIPRASIDONE TREATMENT OF TOURETTE'S SYNDROME IN CHILDRENM01RR006022 · NCRR · YALE UNIVERSITY · PI KESSLER, DAVID A · 1990 to 2003
$6.7M
MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITSU10HD021397 · NICHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DUARA, SHAHNAZ · 1991 to 2006
$6.7M
NCATS NIH HHS U01 TR001792NCRR NIH HHS M01 RR006022NCRR NIH HHS M01 RR007122NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR016587NCRR NIH HHS UL1 RR024979NEI NIH HHS R01 EY015130NEI NIH HHS R01 EY017011NHGRI NIH HHS U01 HG004423NHLBI NIH HHS R01 HL105702NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053109NICHD NIH HHS UG1 HD040492U.S. Department of Health & Human Services | National Institutes of Health (NIH) see belowU.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) U01 HG4423
6 · The paper itself

Abstract

objectiveTo test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study. STUDY

designExtremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis.

resultOne hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development.

conclusionGenetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.

Indexed as

Infant, Extremely Low Birth WeightInfant, Premature, DiseasesBirth WeightCerebral HemorrhageChildHumansInfantInfant, NewbornInfant, Premature

Identifiers

PMID32978526
PMCPMC7889697
OpenAlexW3087891540

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.