Evidence map›Paper›PMID 32978524›Full record

SynthesisProstate cancer and prostatic diseases2021

Depression, anxiety, and suicidality in patients with prostate cancer: a systematic review and meta-analysis of observational studies.

Oliver Brunckhorst, Safiya Hashemi, Anastasia Martin, Gincy George, Mieke Van Hemelrijck, Prokar Dasgupta, Robert Stewart, Kamran Ahmed

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Prostate cancer and prostatic diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Global prevalence and risk factors of suicidality among head and neck cancer patients-systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  12. Reconceptualizing the ethics of diagnosis: a Foucauldian framework.Philosophy, ethics, and humanities in medicine : PEHM · 2026
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  20. The interplay and influence of anxiety and depression among men with early-stage prostate cancer and their close allies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oliver BrunckhorstMRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK. oliver.brunckhorst@kcl.ac.uk.ORCID http://orcid.org/0000-0002-2073-922X
Safiya HashemiMRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.
Anastasia MartinMRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.
Gincy GeorgeTranslational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Mieke Van HemelrijckTranslational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
Prokar DasguptaMRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.
Robert StewartInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Kamran AhmedMRC Centre for Transplantation, Guy's Hospital Campus, King's College London, King's Health Partners, London, UK.

Funding

Department of HealthMedical Research Council MC_PC_17214Medical Research Council MR/T045302/1Medical Research Council MR/V049879/1
6 · The paper itself

Abstract

backgroundPsychiatric implications of prostate cancer are increasingly recognised, having important effects on oncological and functional outcomes. However, findings for co-occurring depression, anxiety, and suicidality remain variable. Therefore, this review of observational studies aimed to establish best estimates of the prevalence and rates of these outcomes in prostate cancer patients.

methodsA systematic literature search was conducted using MEDLINE, Scopus, PsycInfo, and Cochrane Library databases from inception up to 26 May 2020. Observational studies using validated methods for evaluating prevalences of depression, anxiety and suicidal ideation, or suicide mortality rates post prostate cancer diagnosis were included. Random effect models were used to calculate pooled prevalences of depressive and anxiety symptoms or disorders, and suicidal ideation post diagnosis. Additionally, pooled crude suicide mortality rates per 100,000 person years were calculated. Heterogeneity was explored using a stratified analysis.

resultsOf 3537 articles screened, 117 were included. Pooled prevalence for depressive disorders was 5.81% (95% CI 4.36-7.46) in 11 studies, representing 655,149 patients. Significant depressive symptoms were identified in 17.07% (15.14-19.09) across 32,339 patients and 76 studies. In total, 16.86% (14.92-18.89) had significant anxiety symptoms in 56 studies combining 24,526 patients. In 6,173 patients and eight studies, recent suicidal ideation was present in 9.85% (7.31-12.70). Crude suicide mortality rate after diagnosis was 47.1 (39.85-54.96) per 100,000 person years in 12 studies. Significant heterogeneity was seen with potential sources identified through our sensitivity analysis including diagnostic method utilised, study size and location of study.

conclusionsThe mental health impact in patients with prostate cancer is significant. Depressive, anxiety, and suicidal symptoms were common. Additionally, a high suicide mortality rate was identified when compared to general population estimates. Screening of patients and integration of physical and mental health care should be evaluated further to improve quality of life and functional outcomes.

Indexed as

Quality of LifeSuicidal IdeationAnxietyDepressionHumansMaleObservational Studies as TopicPrevalenceProstatic NeoplasmsSuicide

Identifiers

PMID32978524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.