ArticleScientific reports2020
Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Comprehensive database of track-structure simulations on DNA damage by H-Fe ions up to 1 GeV/u for space radiation biology.Scientific reports · 2026Article
- Predicting DNA damage yields and assessing beam quality for protons and carbon ions using a DBSCAN algorithm.Scientific reports · 2026Article
- Article
- Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom.Scientific reports · 2025Article
- Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS.Biotech (Basel (Switzerland)) · 2024Article
- Track Structure-Based Simulations on DNA Damage Induced by Diverse Isotopes.International journal of molecular sciences · 2022Article
- Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage.Radiation research · 2022Article
- The Effect of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for Cells Irradiated with Grenz Rays.Cancers · 2022Article
- Chromatin and the Cellular Response to Particle Radiation-Induced Oxidative and Clustered DNA Damage.Frontiers in cell and developmental biology · 2022Review
- Impact of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for a 62-MeV Therapeutic Proton Beam.Cancers · 2021Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Track structure based simulations valuably complement experimental research on biological effects of ionizing radiation. They provide information at the highest level of detail on initial DNA damage induced by diverse types of radiation. Simulations with the biophysical Monte Carlo code PARTRAC have been used for testing working hypotheses on radiation action mechanisms, for benchmarking other damage codes and as input for modelling subsequent biological processes. To facilitate such applications and in particular to enable extending the simulations to mixed radiation field conditions, we present analytical formulas that capture PARTRAC simulation results on DNA single- and double-strand breaks and their clusters induced in cells irradiated by ions ranging from hydrogen to neon at energies from 0.5 GeV/u down to their stopping. These functions offer a means by which radiation transport codes at the macroscopic scale could easily be extended to predict biological effects, exploiting a large database of results from micro-/nanoscale simulations, without having to deal with the coupling of spatial scales and running full track-structure calculations.
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