ArticleScientific reports2020
A vertebrate model to reveal neural substrates underlying the transitions between conscious and unconscious states.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Article
- Functionalization of 1,3-Diisopropylbenzene to Probe the Antagonism of Propofol Anesthesia.ACS chemical neuroscience · 2025Article
- Brain-Wide Impacts of Sedation on Spontaneous Activity and Auditory Processing in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets.Anesthesiology · 2024Review
- Antagonism of Propofol Anesthesia by Alkyl-fluorobenzene Derivatives.Research square · 2024Article
- Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol.ACS chemical neuroscience · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
The field of neuropharmacology has not yet achieved a full understanding of how the brain transitions between states of consciousness and drug-induced unconsciousness, or anesthesia. Many small molecules are used to alter human consciousness, but the repertoire of underlying molecular targets, and thereby the genes, are incompletely understood. Here we describe a robust larval zebrafish model of anesthetic action, from sedation to general anesthesia. We use loss of movement under three different conditions, spontaneous movement, electrical stimulation or a tap, as a surrogate for sedation and general anesthesia, respectively. Using these behavioral patterns, we find that larval zebrafish respond to inhalational and IV anesthetics at concentrations similar to mammals. Additionally, known sedative drugs cause loss of spontaneous larval movement but not to the tap response. This robust, highly tractable vertebrate model can be used in the detection of genes and neural substrates involved in the transition from consciousness to unconsciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.