ArticleScientific reports2020
Impairment of synaptic plasticity and novel object recognition in the hypergravity-exposed rats.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- Article
- Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model.Scientific reports · 2025Article
- Article
- A Sensitive Homecage-Based Novel Object Recognition Task for Rodents.Frontiers in behavioral neuroscience · 2021Article
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Authors and funding
5 authors.
Funding
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Abstract
The gravity is necessary for living organisms to operate various biological events including hippocampus-related functions of learning and memory. Until now, it remains inconclusive how altered gravity is associated with hippocampal functions. It is mainly due to the difficulties in generating an animal model experiencing altered gravity. Here, we demonstrate the effects of hypergravity on hippocampus-related functions using an animal behavior and electrophysiology with our hypergravity animal model. The hypergravity (4G, 4 weeks) group showed impaired synaptic efficacy and long-term potentiation in CA1 neurons of the hippocampus along with the poor performance of a novel object recognition task. Our studies suggest that altered gravity affects hippocampus-related cognitive functions, presumably through structural and functional adaptation to various conditions of gravity shift.
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