Evidence map›Paper›PMID 32978411›Full record

ArticleScientific reports2020

Bioenergetic effects of hydrogen sulfide suppress soluble Flt-1 and soluble endoglin in cystathionine gamma-lyase compromised endothelial cells.

Lissette Carolina Sanchez-Aranguren, Shakil Ahmad, Irundika H K Dias, Faisal A Alzahrani, Homira Rezai, Keqing Wang, Asif Ahmed

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A Metabolic Paradigm for Hydrogen Sulfide SignalingAntioxidants & redox signaling · 2023
    Review
  6. Article
  7. Review
  8. Trends in HAntioxidants (Basel, Switzerland) · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Lissette Carolina Sanchez-ArangurenAston Medical Research Institute, Aston Medical School, Birmingham, UK.
Shakil AhmadAston Medical Research Institute, Aston Medical School, Birmingham, UK.
Irundika H K DiasAston Medical Research Institute, Aston Medical School, Birmingham, UK.
Faisal A AlzahraniMirzyme Therapeutics, Innovation Birmingham Campus, Faraday Wharf, Holt Street, Birmingham, B7 4BB, UK.
Homira RezaiMirzyme Therapeutics, Innovation Birmingham Campus, Faraday Wharf, Holt Street, Birmingham, B7 4BB, UK.
Keqing WangAston Medical Research Institute, Aston Medical School, Birmingham, UK.
Asif AhmedAston Medical Research Institute, Aston Medical School, Birmingham, UK. asif.ahmed@mirzyme.com.
Aston University · GBKing Abdulaziz University · SA

Funding

British Heart Foundation FS/15/72/31676Medical Research Council G0700288
6 · The paper itself

Abstract

Endothelial dysfunction is a hallmark of preeclampsia, a life-threatening complication of pregnancy characterised by hypertension and elevated soluble Fms-Like Tyrosine Kinase-1 (sFlt-1). Dysregulation of hydrogen sulfide (H

Indexed as

Energy MetabolismAir PollutantsCystathionine gamma-LyaseEndoglinEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsHydrogen SulfideMitochondriaReactive Oxygen SpeciesVascular Endothelial Growth Factor Receptor-1Air PollutantsCystathionine gamma-LyaseEndoglinFLT1 protein, humanHydrogen SulfideReactive Oxygen SpeciesVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID32978411
PMCPMC7519095
OpenAlexW3088427828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.