ArticleNature communications2020
Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A defined microbial community remodels host metabolism and pathogen resistance inbioRxiv : the preprint server for biology · 2026Article
- The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine.Genetics · 2026Article
- Ultrasound-targeted microbubble destruction enhances RSL3-induced ferroptosis in anaplastic thyroid carcinoma.iScience · 2026Article
- Dietary and metabolic reprogramming alleviates neurodegeneration: a review of mechanisms and clinical implications.Frontiers in nutrition · 2026Review
- Forward genetics ineLife · 2025Article
- Targeting ferroptosis: a novel insight into thyroid cancer therapy.Frontiers in endocrinology · 2025Review
- Calcineurin inhibition enhanceseLife · 2024Article
- Exploring the association between circRNA expression and pediatric obesity based on a case-control study and related bioinformatics analysis.BMC pediatrics · 2023Review
- Multi-Omics Analysis of Genes Encoding Proteins Involved in Alpha-Linolenic Acid Metabolism in Chicken.Foods (Basel, Switzerland) · 2023Article
- Opposing action of the FLR-2 glycoprotein hormone and DRL-1/FLR-4 MAP kinases balance p38-mediated growth and lipid homeostasis in C. elegans.PLoS biology · 2023Article
- The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2.Aging cell · 2023Article
- A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity.Nature communications · 2023Article
- Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction.PloS one · 2023Article
- Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans.Redox biology · 2022Article
- Lipid metabolism and ageing in Caenorhabditis elegans: a complex interplay.Biogerontology · 2022Review
- Dietary regulation in health and disease.Signal transduction and targeted therapy · 2022Review
- Lysosome lipid signalling from the periphery to neurons regulates longevity.Nature cell biology · 2022Article
- PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.Nature communications · 2022Article
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Worms, Fat, and Death:Metabolites · 2021Review
Corrections and comments
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Authors and funding
9 authors.
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Abstract
The metabolic state of an organism instructs gene expression modalities, leading to changes in complex life history traits, such as longevity. Dietary restriction (DR), which positively affects health and life span across species, leads to metabolic reprogramming that enhances utilisation of fatty acids for energy generation. One direct consequence of this metabolic shift is the upregulation of cytoprotective (CyTP) genes categorized in the Gene Ontology (GO) term of "Xenobiotic Detoxification Program" (XDP). How an organism senses metabolic changes during nutritional stress to alter gene expression programs is less known. Here, using a genetic model of DR, we show that the levels of polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA) and eicosapentaenoic acid (EPA), are increased following DR and these PUFAs are able to activate the CyTP genes. This activation of CyTP genes is mediated by the conserved p38 mitogen-activated protein kinase (p38-MAPK) pathway. Consequently, genes of the PUFA biosynthesis and p38-MAPK pathway are required for multiple paradigms of DR-mediated longevity, suggesting conservation of mechanism. Thus, our study shows that PUFAs and p38-MAPK pathway function downstream of DR to help communicate the metabolic state of an organism to regulate expression of CyTP genes, ensuring extended life span.
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