Evidence map›Paper›PMID 32978327›Full record

ArticleMolecular pharmacology2020

Reduced Activation of the Synaptic-Type GABA

Spencer R Pierce, Allison L Germann, Alex S Evers, Joe Henry Steinbach, Gustav Akk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Massive Activation of GABABiomolecules · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution.

Spencer R PierceDepartment of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Allison L GermannDepartment of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Alex S EversDepartment of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Joe Henry SteinbachDepartment of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Gustav AkkDepartment of Anesthesiology (S.R.P., A.L.G., A.S.E., J.H.S., G.A.) and the Taylor Family Institute for Innovative Psychiatric Research (A.S.E., J.H.S., G.A.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric Research

Funding

MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R01 GM108799
6 · The paper itself

Abstract

Synaptic GABA

Indexed as

AnimalsCells, CulturedDose-Response Relationship, DrugGABA-A Receptor Agonistsgamma-Aminobutyric AcidHumansOocytesPatch-Clamp TechniquesPregnanoloneReceptors, GABA-ARecombinant ProteinsSynaptic PotentialsTime FactorsXenopus laevisGABA-A Receptor Agonistsgamma-Aminobutyric AcidPregnanoloneReceptors, GABA-ARecombinant Proteins

Identifiers

PMID32978327
PMCPMC7673486
OpenAlexW3087901828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.