ArticlePediatrics2020
Accuracy of a Modified qSOFA Score for Predicting Critical Care Admission in Febrile Children.
Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Improved 28-day mortality prediction by combining Lactate Dehydrogenase-to-Albumin Ratio(LAR) to lactate-enhanced Sequential Organ Failure Assessment (SOFA) score in patients with sepsis: a derivation and validation study.BMC infectious diseases · 2026Article
- Development and multicenter validation of an explainable machine learning diagnostic criteria for pediatric abdominal sepsis.NPJ digital medicine · 2026Article
- Factors associated with positive blood cultures in children in nine African and Asian countries: the ACORN2 surveillance network.BMJ global health · 2025Article
- Characteristics of a revised quick sequential organ failure assessment score (RqSOFA) to predict in-hospital mortality of patients visiting the emergency department via ambulance: an observational cohort study.Internal and emergency medicine · 2025Observational
- Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study.The Lancet. Child & adolescent health · 2025Observational
- Predicting hospital admissions, ICU utilization, and prolonged length of stay among febrile pediatric emergency department patients using incomplete and imbalanced electronic health record (EHR) data strategies.International journal of medical informatics · 2025Article
- Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) predicts mortality in patients with febrile illness in southern Mozambique.Communications medicine · 2025Article
- Machine Learning for Predicting Critical Events Among Hospitalized Children.JAMA network open · 2025Article
- Identification of distinct clinical profiles of sepsis risk in paediatric emergency department patients using Bayesian profile regression.BMJ paediatrics open · 2025Article
- Assessing children who are acutely ill in general practice using the National PEWS and LqSOFA clinical scores: a retrospective cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU.Annals of medicine · 2024Article
- Comparison of modified quick Sequential Organ Failure Assessment models as triage tools for febrile patients.Clinical and experimental emergency medicine · 2024Article
- Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world.The Lancet. Digital health · 2024Review
- Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department.BMC emergency medicine · 2024Article
- Burden of child mortality from malaria in high endemic areas: Results from the CHAMPS network using minimally invasive tissue sampling.The Journal of infection · 2024Article
- Identifying critically ill children in Malawi: A modified qSOFA score for low-resource settings.PLOS global public health · 2024Article
- External validation of clinical severity scores to guide referral of paediatric acute respiratory infections in resource-limited primary care settings.Scientific reports · 2023Article
- Validation of Childhood Pneumonia Prognostic Models for Use in Emergency Care Settings.Journal of the Pediatric Infectious Diseases Society · 2023Article
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Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
BACKGROUND AND
objectivesThe identification of life-threatening infection in febrile children presenting to the emergency department (ED) remains difficult. The quick Sequential Organ Failure Assessment (qSOFA) was only derived for adult populations, implying an urgent need for pediatric scores. We developed and validated a novel, adapted qSOFA score (Liverpool quick Sequential Organ Failure Assessment [LqSOFA]) and compared its performance with qSOFA, Pediatric Early Warning Score (PEWS), and National Institute for Health and Care Excellence (NICE) high-risk criteria in predicting critical care (CC) admission in febrile children presenting to the ED.
methodsThe LqSOFA (range, 0-4) incorporates age-adjusted heart rate, respiratory rate, capillary refill, and consciousness level on the Alert, Voice, Pain, Unresponsive scale. The primary outcome was CC admission within 48 hours of ED presentation, and the secondary outcome was sepsis-related mortality. LqSOFA, qSOFA, PEWS, and NICE high-risk criteria scores were calculated, and performance characteristics, including area under the receiver operating characteristic curve, were calculated for each score.
resultsIn the initial (
conclusionsIn this large study, we demonstrate improved performance of the LqSOFA over qSOFA in identifying febrile children at risk for CC admission and sepsis-related mortality. Further validation is required in other settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.