Evidence map›Paper›PMID 32978279›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Identification of a Distal Locus Enhancer Element That Controls Cell Type-Specific

Luke D Jasenosky, Aya Nambu, Alla V Tsytsykova, Shahin Ranjbar, Viraga Haridas, Laurens Kruidenier, David F Tough, Anne E Goldfeld

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Luke D JasenoskyProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Aya NambuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-2797-6420
Alla V TsytsykovaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Shahin RanjbarProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.
Viraga HaridasProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0001-9174-028X
Laurens KruidenierPrometheus Biosciences, San Diego, CA 92121; and.
David F ToughAdaptive Immunity Research Unit, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, United Kingdom.ORCID 0000-0003-3585-0649
Anne E GoldfeldProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; anne.goldfeld@childrens.harvard.edu.
Boston Children's Hospital · USGlaxoSmithKline (United Kingdom) · GBPrometheus Biosciences (United States) · US

Funding

Checkpoints of TNF Gene RegulationR01GM076685 · NIGMS · IMMUNE DISEASE INSTITUTE, INC. · PI GOLDFELD, ANNE · 2006 to 2019
$5.2M
NIGMS NIH HHS R01 GM076685
6 · The paper itself

Abstract

The human

Indexed as

AcetylationBinding SitesCD4-Positive T-LymphocytesClustered Regularly Interspaced Short Palindromic RepeatsConserved SequenceEnhancer Elements, GeneticGene ExpressionHistonesHumansLeukocytes, MononuclearLymphotoxin-alphaPromoter Regions, GeneticProtein BindingRNA, MessengerRNA Polymerase IITHP-1 CellsHistonesLymphotoxin-alphaRNA, MessengerRNA Polymerase IITumor Necrosis Factor-alpha

Identifiers

PMID32978279
PMCPMC7576113
OpenAlexW3089141764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.