Evidence map›Paper›PMID 32978260›Full record

ArticleThe Journal of biological chemistry2020

α

Seandean Lykke Harwood, Nadia Sukusu Nielsen, Kathrine Tejlgård Jensen, Peter Kresten Nielsen, Ida B Thøgersen, Jan J Enghild

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Engineering New Protease Inhibitors Using αMethods in molecular biology (Clifton, N.J.) · 2024
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Seandean Lykke HarwoodDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark; General Research Technologies, Novo Nordisk A/S, Måløv, Denmark.
Nadia Sukusu NielsenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Kathrine Tejlgård JensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Peter Kresten NielsenGeneral Research Technologies, Novo Nordisk A/S, Måløv, Denmark.
Ida B ThøgersenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Jan J EnghildDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. Electronic address: jje@mbg.au.dk.
Aarhus University · DKNovo Nordisk (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteins in the α-macroglobulin (αM) superfamily use thiol esters to form covalent conjugation products upon their proteolytic activation. αM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (

Indexed as

Acetylationalpha-MacroglobulinsAmino Acid SequenceChromatography, High Pressure LiquidEstersHistidineHumansHydrogen-Ion ConcentrationHydroxidesMutagenesis, Site-DirectedPeptidesProtease InhibitorsRecombinant ProteinsSequence AlignmentSulfhydryl CompoundsTandem Mass SpectrometryA2ML1 protein, humanalpha-MacroglobulinsEstersHistidinehydroxide ionHydroxidesPeptidesProtease InhibitorsRecombinant ProteinsSulfhydryl CompoundsThermolysinA2ML1alpha-2-macroglobulinalpha 2 macroglobulin like protein 1complementinhibition mechanismmutagenesismutagenesis in vitroproteaseprotease inhibitorprotein crosslinkingthiol esterα2-macroglobulin

Identifiers

PMID32978260
PMCPMC7864068
OpenAlexW3088565447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.