Evidence map›Paper›PMID 32978219›Full record

ArticleEuropean journal of hospital pharmacy : science and practice2022

External contamination of antineoplastic drug vials: an occupational risk to consider.

Camille Cotteret, Philippe-Henri Secretan, Laurence Gilles-Afchain, Julia Rousseau, Fabrice Vidal, Gabriel Salguero-Hernandez, Jonathan Batista, Vicky Valverde, Jerome Guitton, Salvatore Cisternino and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of hospital pharmacy : science and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Proactive risk assessment and nursing risk management in chemotherapy drugs: FMECA methodology results.Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management · 2026
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Camille CotteretPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Philippe-Henri SecretanPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Laurence Gilles-AfchainPharmacy, Centre Régional de Lutte Contre le Cancer Centre Léon Bérard, Lyon, France.
Julia RousseauPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Fabrice VidalPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Gabriel Salguero-HernandezPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Jonathan BatistaPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Vicky ValverdePharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Jerome GuittonPharmacy, Centre Régional de Lutte Contre le Cancer Centre Léon Bérard, Lyon, France.
Salvatore CisterninoPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France.
Joël SchlatterPharmacie clinique, Hôpital universitaire Necker-Enfants Malades, Paris, France joel.schlatter@aphp.fr.ORCID 0000-0002-4443-8843
Hôpital Necker-Enfants Malades · FRCentre Léon Bérard · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk management for workers involved in the handling and preparation of cytotoxic drugs is challenging. This study aims to investigate drug contamination of the exterior surfaces of cytotoxic drug vials. Two batches of commercially available cytotoxic drugs in unprotected vials (ifosfamide, etoposide phosphate and cyclophosphamide) and plastic shrink wrap vials (doxorubicin, cytarabine and busulfan) were tested without removing the flip-off cap or the plastic wrap, and without prewashing. The results showed significant trace amounts of cytotoxic drugs on the exterior surfaces in both unprotected (eg, cyclophosphamide, ifosfamide) and protected plastic shrink wrap vials (eg, cytarabine), indicating that the secondary packaging of protected vials does not systematically prevent exposure to the handlers. These results focus on the need for guidelines to prevent cytotoxic vial contamination and safety recommendations for staff in the handling and storage of these vials.

Indexed as

Antineoplastic AgentsOccupational ExposureCyclophosphamideCytarabineDrug ContaminationDrug PackagingEnvironmental MonitoringHumansIfosfamidePlasticsAntineoplastic AgentsCyclophosphamideCytarabineIfosfamidePlasticsantineoplastic agentschemical safetycontrolledenvironmentoccupational medicinesafety

Identifiers

PMID32978219
PMCPMC9660623
OpenAlexW3088760931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.