ArticleScience advances2020
Structure and sequence features of mussel adhesive protein lead to its salt-tolerant adhesion ability.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Aqueous lignin adhesive for high-performance wood bonding.Science advances · 2026Article
- A biofilm-derived peptide as an underwater adhesive.bioRxiv : the preprint server for biology · 2026Article
- Catechol-Containing Poly(2-isopropyl-2-oxazoline): Synthesis and Thermoresponsive Behavior in Aqueous Salt Solutions.Macromolecular rapid communications · 2026Article
- Condensate-based sequestration enables high-efficiency synthesis of mussel foot protein Mcofp-3.Applied and environmental microbiology · 2026Article
- Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-β3 encapsulation for enhanced tendon-bone healing in rotator cuff tears.Materials today. Bio · 2026Article
- Post-translational modifications of silk proteins.RSC chemical biology · 2026Review
- Identification and characterization of a wet adhesive protein extracted fromProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Data-driven de novo design: revolutionizing super-adhesive hydrogels for underwater applications.International journal of biological sciences · 2026Article
- Development and Functional Characterization of Recombinant Mussel Adhesive Protein for Anti-Oxidative and Anti-Aging Therapeutic Applications.International journal of molecular sciences · 2025Article
- Article
- Light-Driven PAA Adhesive: A Green Bonding Platform Integrating High-Performance, Environmental Resilience, and Closed-Loop Recyclability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Highly Soluble Mussel Foot Protein Enhances Antioxidant Defense and Cytoprotection via PI3K/Akt and Nrf2/HO-1 Pathways.Antioxidants (Basel, Switzerland) · 2025Article
- Mussel-InspiredACS omega · 2025Article
- Pharmacological effects and application prospects of mussel adhesive proteins.Frontiers in pharmacology · 2025Review
- Molecular Crowding: The History and Development of a Scientific Paradigm.Chemical reviews · 2024Review
- Tough Hydrogels with Different Toughening Mechanisms and Applications.International journal of molecular sciences · 2024Review
- Mussel inspired 3D elastomer enabled rapid calvarial bone regeneration through recruiting more osteoprogenitors from the dura mater.Regenerative biomaterials · 2024Article
- Enzymatic polymerization of enantiomericNature communications · 2023Article
- Bi-terminal fusion of intrinsically-disordered mussel foot protein fragments boosts mechanical strength for protein fibers.Nature communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mussels can strongly adhere to hydrophilic minerals in sea habitats by secreting adhesive proteins. The adhesion ability of these proteins is often attributed to the presence of Dopa derived from posttranslational modification of Tyr, whereas the contribution of structural feature is overlooked. It remains largely unknown how adhesive proteins overcome the surface-bound water layer to establish underwater adhesion. Here, we use molecular dynamics simulations to probe the conformations of adhesive protein Pvfp-5β and its salt-tolerant underwater adhesion on superhydrophilic mica. Dopa and positively charged basic residues form pairs, in this intrinsically disordered protein, and these residue pairs can lead to firm surface binding. Our simulations further suggest that the unmodified Tyr shows similar functions on surface adhesion by forming pairing structure with a positively charged residue. We confirm the presence of these residue pairs and verify the strong binding ability of unmodified proteins using nuclear magnetic resonance spectroscopy and lap shear tests.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.