Evidence map›Paper›PMID 32977949›Full record

ArticleBiochemical and biophysical research communications2020

Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage.

Tzu-Hau Shi, Yi-Long Huang, Chiao-Che Chen, Wen-Chieh Pi, Yu-Ling Hsu, Lee-Chiang Lo, Wei-Yi Chen, Shu-Ling Fu, Chao-Hsiung Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. A Systematic Review on the Antimicrobial Activity of Andrographolide.Journal of microbiology and biotechnology · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Natural Products for the Management of Asthma and COPD.Handbook of experimental pharmacology · 2025
    Review
  9. Journal of traditional and complementary medicine · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. COVID-19 Therapeutic Potential of Natural Products.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tzu-Hau ShiDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Biomedical Industry Ph.D. Program, National Yang-Ming University, Taipei, 112, Taiwan.
Yi-Long HuangAging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan.
Chiao-Che ChenDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan.
Wen-Chieh PiInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
Yu-Ling HsuDepartment of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
Lee-Chiang LoDepartment of Chemistry, National Taiwan University, Taipei, 106, Taiwan.
Wei-Yi ChenInstitute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, 112, Taiwan.
Shu-Ling FuInstitute of Traditional Medicine, National Yang-Ming University, Taipei, 112, Taiwan. Electronic address: slfu@ym.edu.tw.
Chao-Hsiung LinDepartment of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, 112, Taiwan; Aging and Health Research Center, National Yang-Ming University, Taipei, 112, Taiwan; Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, 112, Taiwan. Electronic address: chlin2@ym.edu.tw.
National Yang Ming Chiao Tung University · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by 2019 novel coronavirus (2019-nCoV) has been a crisis of global health, whereas the effective vaccines against 2019-nCoV are still under development. Alternatively, utilization of old drugs or available medicine that can suppress the viral activity or replication may provide an urgent solution to suppress the rapid spread of 2019-nCoV. Andrographolide is a highly abundant natural product of the medicinal plant, Andrographis paniculata, which has been clinically used for inflammatory diseases and anti-viral therapy. We herein demonstrate that both andrographolide and its fluorescent derivative, the nitrobenzoxadiazole-conjugated andrographolide (Andro- NBD), suppressed the main protease (M

Indexed as

BetacoronavirusCatalytic DomainCoronavirus 3C ProteasesCysteine EndopeptidasesDiterpenesFluorescent DyesMolecular Docking SimulationProtease InhibitorsProtein ConformationProtein MultimerizationSARS-CoV-2Severe acute respiratory syndrome-related coronavirusViral Nonstructural ProteinsandrographolideCoronavirus 3C ProteasesCysteine EndopeptidasesDiterpenesFluorescent DyesProtease InhibitorsViral Nonstructural Proteins2019-nCoVAndrographolideMain proteaseSARS-CoV

Identifiers

PMID32977949
PMCPMC7447262
OpenAlexW3080887454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.