ArticleWorld journal of emergency surgery : WJES2020
Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: a single-center analysis of 2570 patients.
Article in World journal of emergency surgery : WJES, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- [Thinking, evaluating, and replenishing the fibrinogen hemostatic strategy in neurosurgery].Revista medica del Instituto Mexicano del Seguro Social · 2026Review
- Association between hemostatic changes and contusion volume in traumatic brain injury: an observational cohort study.Acta neurochirurgica · 2026Observational
- Risk warning of systemic immune-inflammation index and coagulation parameters for hospital-acquired pneumonia in patients with traumatic brain injury.American journal of translational research · 2026Article
- An Interpretable Machine Learning Model for Predicting Early Neurological Deterioration Following Posttraumatic Acute Diffuse Brain Swelling.Neurocritical care · 2025Article
- Abdominal and pelvic surgery in traumatic brain injury patients; a registry-based retrospective analysis.BMC surgery · 2025Article
- Hemostatic disturbances in traumatic brain injury: from mechanism to management.Acta neurochirurgica · 2025Review
- Review
- High-dimensional analysis of injured patients reveals distinct circulating proteomic profiles in plasma vs. whole blood resuscitation.Cell reports. Medicine · 2025Article
- Article
- The Prognostic Value of D-Dimer Levels for Injury Outcomes in Trauma Patients: A Systematic Review and Meta-Analysis.Bulletin of emergency and trauma · 2025Review
- Effect of pain nursing intervention on patients with craniocerebral trauma combined with ocular trauma after decompressive craniectomy.Pakistan journal of medical sciences · 2024Article
- Prognostication in Epilepsy with Integrated Analysis of Blood Parameters and Clinical Data.Journal of clinical medicine · 2024Article
- Letter to editor: Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience.Neurosurgical review · 2024Article
- The improvement of fibrinogen, Ang-1, VEGF, BDNF in post-operative patients with brain trauma through target task-oriented phase training.Journal of medical biochemistry · 2024Article
- Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation.Journal of neuroinflammation · 2024Article
- The significance of admission blood lactate and fibrinogen in pediatric traumatic brain injury: a single-center clinical study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience.Neurosurgical review · 2024Article
- Establishment and validation of a bad outcomes prediction model based on EEG and clinical parameters in prolonged disorder of consciousness.Frontiers in human neuroscience · 2024Article
- Predictive value of Caprini risk assessment model, D-dimer, and fibrinogen levels on lower extremity deep vein thrombosis in patients with spontaneous intracerebral hemorrhage.Frontiers in neurology · 2024Article
- Knowledge and attitudes toward mild traumatic brain injury among patients and family members.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to determine the incidence of TBI-associated hypofibrinogenemia in patients with TBI and to evaluate the prognostic value of fibrinogen level with respect to mortality and clinical outcomes.
methodsA total of 2570 consecutive TBI patients were retrospectively studied. Prognostic evaluations were determined using the Glasgow Outcome Score (GOS) assessment 3 months after injury. The shape of the relationship between fibrinogen level and mortality or outcome was examined using cubic spline functions. Logistic regression analyses were conducted to identify the association between fibrinogen level and 3-month functional outcomes.
resultsFibrinogen concentrations < 2 g/L were observed in 992 (38.6%) patients at the time of admission. Multivariate analyses showed that for patients with fibrinogen levels < 2.0 g/L, those levels were an independent prognostic factor for 3-month mortality (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.89-0.93; P < .001). By contrast, for patients with fibrinogen levels < 2.5 g/L, the levels were an independent prognostic factor for favorable outcomes at 3 months (OR, 1.654; 95% CI, 1.186-2.306; P = .003). Similar results were also seen for patients with fibrinogen levels > 3.0 g/L, with the levels being an independent prognostic factor for favorable outcomes at 3 months (OR, 0.771; 95% CI, 0.607-0.979; P = .033).
conclusionsFibrinogen is an independent prognostic factor for clinical outcomes in TBI patients. Maintaining the level of fibrinogen between 2.5 and 3 g/L may improve clinical outcomes in patients with TBI.
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