ArticleBMC evolutionary biology2020
Mitochondrial-nuclear coadaptation revealed through mtDNA replacements in Saccharomyces cerevisiae.
Article in BMC evolutionary biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Disruption of mitonuclear coadaptation and compensatory evolution after an extreme dietary shift in carnivorous butterflies.Molecular biology and evolution · 2026Article
- Comparative Mitogenomics Reveals Intron Dynamics and Mitochondrial Gene Expression Shifts in Domesticated and WildJournal of fungi (Basel, Switzerland) · 2026Article
- The role of mitotype variation and positive epistasis in trait differences between Saccharomyces species.Genetics · 2026Article
- Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans.Molecular biology and evolution · 2025Article
- De novo genome assembly, inversion detection, and worldwide adaptation on the invasive species Styela plicata.Scientific reports · 2025Article
- Mitonuclear Discordance of Beetles Shaped by Incomplete Lineage Sorting and Introgression Under Loose Interaction Mechanism.Molecular biology and evolution · 2025Article
- Exploring the Impact of Mitonuclear Discordance on Disease in Latin American Admixed Populations.Genes · 2025Article
- Mitochondrial Genome Instability inBiology · 2024Article
- Exploring Mitochondrial Heterogeneity and Evolutionary Dynamics inInternational journal of molecular sciences · 2024Article
- Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes.Current opinion in genetics & development · 2023Review
- Mitochondrial Genome Diversity across the Subphylum Saccharomycotina.bioRxiv : the preprint server for biology · 2023Article
- Disentangling the Taxonomy, Systematics, and Life History of the Spider-Parasitic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Evolutionary Trajectories are Contingent on Mitonuclear Interactions.Molecular biology and evolution · 2023Article
- Mapping mitonuclear epistasis using a novel recombinant yeast population.PLoS genetics · 2023Article
- Mitochondrial genome diversity across the subphylum Saccharomycotina.Frontiers in microbiology · 2023Article
- Enforcement of Postzygotic Species Boundaries in the Fungal Kingdom.Microbiology and molecular biology reviews : MMBR · 2022Review
- Compensatory Genetic and Transcriptional Cytonuclear Coordination in Allopolyploid Lager Yeast (Saccharomyces pastorianus).Molecular biology and evolution · 2022Article
- Article
- Mitonuclear Genetic Interactions in the BasidiomyceteFrontiers in fungal biology · 2021Article
- Global Characterization of Fungal Mitogenomes: New Insights on Genomic Diversity and Dynamism of Coding Genes and Accessory Elements.Frontiers in microbiology · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundMitochondrial function requires numerous genetic interactions between mitochondrial- and nuclear- encoded genes. While selection for optimal mitonuclear interactions should result in coevolution between both genomes, evidence for mitonuclear coadaptation is challenging to document. Genetic models where mitonuclear interactions can be explored are needed.
resultsWe systematically exchanged mtDNAs between 15 Saccharomyces cerevisiae isolates from a variety of ecological niches to create 225 unique mitochondrial-nuclear genotypes. Analysis of phenotypic profiles confirmed that environmentally-sensitive interactions between mitochondrial and nuclear genotype contributed to growth differences. Exchanges of mtDNAs between strains of the same or different clades were just as likely to demonstrate mitonuclear epistasis although epistatic effect sizes increased with genetic distances. Strains with their original mtDNAs were more fit than strains with synthetic mitonuclear combinations when grown in media that resembled isolation habitats.
conclusionsThis study shows that natural variation in mitonuclear interactions contributes to fitness landscapes. Multiple examples of coadapted mitochondrial-nuclear genotypes suggest that selection for mitonuclear interactions may play a role in helping yeasts adapt to novel environments and promote coevolution.
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