ArticleBMC cancer2020
Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: a propensity score analysis.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed, 96 citations in OpenAlex.
- Metabolic and Inflammatory Risk Stratification in Resected Cholangiocarcinoma: A Retrospective Exploratory Analysis.Medical sciences (Basel, Switzerland) · 2026Article
- Preoperative neutrophil to lymphocyte ratio as a survival predictor in nonmetastatic colon cancer in a Latin America-based population.Annals of coloproctology · 2026Article
- Article
- Association of the absolute lymphocyte count-to-fibrinogen ratio with the survival outcomes in patients with colorectal cancer.Surgery today · 2026Article
- Clinical impact of the neutrophil-to-lymphocyte ratio on survival in patients with colorectal cancer according to stage: a retrospective study.Surgery today · 2026Article
- Ten-Year Outcomes in Colorectal Cancer-Competing Risks and Patient Vulnerability: A Prospective Multicenter Observational Study.Journal of clinical medicine · 2026Article
- Immune Phenotyping Using Neutrophil-to-Lymphocyte Ratio and Tumor-Infiltrating Lymphocytes Predicts Recurrence in Resected Melanoma.Diagnostics (Basel, Switzerland) · 2026Article
- One Index Does Not Predict All-Hematological Derived Indices Have Different Predictive Value for ICU Mortality in Critically Ill Patients with Non-Infectious Versus Infectious Acute Exacerbation of COPD.Medicina (Kaunas, Lithuania) · 2026Observational
- Clinical and inflammatory biomarkers predicting emergency surgical management decisions and postoperative outcomes in complicated colon cancer.Journal of medicine and life · 2026Article
- Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer.Cancers · 2026Article
- Preoperative Prognostic Score for Patients with Intrahepatic Cholangiocarcinoma Undergoing Curative-Intent Resection.Medical sciences (Basel, Switzerland) · 2026Article
- Coordinated dynamics of circulating neutrophils, regulatory T lymphocytes, myeloid derived suppressor cells and distinct granulocytic subsets reveal a complex immune network in metastatic colorectal cancer.Frontiers in oncology · 2026Article
- Prognostic impact of persistent postoperative neutrophil-to-lymphocyte ratio elevation 1 year after colorectal cancer surgery.Updates in surgery · 2025Article
- Side-Specific Prognostic Factors in Colon Cancer: A Retrospective Analysis of Right- and Left-Sided Tumors.Cancers · 2025Article
- Comparative Prognostic Role of PLR and NLR in Colon Cancer: A Retrospective Analysis of Preoperative Inflammatory Markers.Medicina (Kaunas, Lithuania) · 2025Observational
- Development and validation of predictive models for disease-free survival and overall survival in non-metastatic right-sided colon adenocarcinoma patients based on inflammatory and nutritional indices.BMC gastroenterology · 2025Article
- Early prediction of anastomotic leakage after rectal cancer surgery: Onodera prognostic nutritional index combined with inflammation-related biomarkers.World journal of gastrointestinal surgery · 2025Article
- Clinical Significance of Blood Cell-Derived Inflammation Markers in Assessing Potential Early and Late Postoperative Complications in Patients with Colorectal Cancer: A Systematic Review.Journal of clinical medicine · 2025Review
- Diagnostic value of peripheral blood inflammatory indices for clinicopathological profile of colorectal cancer: a retrospective observational study.BMC gastroenterology · 2025Observational
- Optimal cutpoint of preoperative neutrophil-lymphocyte ratio and associated postoperative prognosis in colorectal cancer patients.International journal of colorectal disease · 2025Article
15 more citing papers are in PubMed but not listed here.
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10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (NLR), in cancer recurrence and death has been increasingly recognized. This study aimed to analyze long-term oncologic outcomes of Stage II-III colon cancer to examine the prognostic value of NLR using a propensity score analysis.
methodsA total of 375 patients with colon cancer underwent radical surgery between 2000 and 2014 at Tokyo Medical University Hospital. Long-term oncologic outcomes of these patients were evaluated according to NLR values. A cut-off NLR of 3.0 was used based on receiver operating characteristic curve analysis. Primary outcomes were overall survival (OS) and relapse-free survival (RFS). An analysis of outcomes according to tumor sidedness was also performed.
resultsPatients with lower NLR values ("lower NLR group") were more likely to have lymph node metastasis compared to those with higher NLR values ("higher NLR group") before case matching. After case matching, clinical outcomes were similar between the two groups. There were no significant differences in 5-year OS and 5-year RFS rates between the two groups before case matching based on propensity scores. After case matching, 5-year OS rates were 94.5% in the lower NLR group (n = 135) and 87.0% in the higher NLR group (n = 135), showing a significant difference (p = 0.042). Five-year RFS rates were 87.8% in the lower NLR group and 77.9% in the higher NLR group, also showing a significant difference (p = 0.032). Among patients with left-sided colon cancer in the matched cohort, 5-year OS and 5-year RFS rates were 95.2 and 87.3% in the lower NLR group (n = 88), respectively, and 86.4 and 79.2% in the higher NLR group (n = 71), respectively, showing significant differences (p = 0.014 and p = 0.047, respectively).
conclusionsThe NLR is an important prognostic factor for advanced colon cancer, especially for left-sided colon cancer.
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