ArticleBMC infectious diseases2020
Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Short-Term Functional Trajectories After Surgery in Older Adults: National Patterns of Loss and Recovery in 436,471 Patients.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- A Rare Presentation of Infective Endocarditis Complicating Severe Aortic Valve Stenosis.Journal of cardiovascular development and disease · 2026Article
- From structural heart lesions to host burden: changing epidemiology and outcomes of native valve infective endocarditis, a nationwide study, 2006-2023.Open heart · 2026Article
- Reply: Management and Imaging Strategies in Pediatric Infective Endocarditis With Mitral Prolapse.JACC. Case reports · 2026Article
- Clinical Severity and Surgical Burden in Drug Use-Associated Infective Endocarditis: A Six-Year Cohort Study.Microorganisms · 2026Article
- Early and late outcomes after aortic valve replacement, mitral valve replacement and mitral valve plasty for native and prosthetic valve endocarditis in The Netherlands.European heart journal. Imaging methods and practice · 2026Article
- Long-term mortality in patients who survive surgery for infective endocarditis versus the background population: a nationwide study.Open heart · 2025Article
- Prognostic factors for long-term mortality after surgery of left-sided infective endocarditis.PloS one · 2025Article
- Burkholderia cepacia Infective Endocarditis of Native Aortic Valve: A Case Report and Review of Literature.Cureus · 2024Article
- The Surgical Outcome of Infective Endocarditis in South Africa over 10 Years: A Retrospective Review.Journal of clinical medicine · 2024Article
- Novel Diagnostic Methods for Infective Endocarditis.International journal of molecular sciences · 2024Review
- Risk assessment for postoperative complications in patients undergoing cardiac surgical procedures.Revista brasileira de enfermagem · 2024Article
- Updates in Culture-Negative Endocarditis.Pathogens (Basel, Switzerland) · 2023Review
- Surgical treatment on infective endocarditis: impact of diabetes on mortality.Cardiovascular diabetology · 2022Observational
- Comorbidity and Prognosis in Octogenarians with Infective Endocarditis.Journal of clinical medicine · 2022Article
- Clinical Characteristics and Risk Factors for in-Hospital Mortality in 240 Cases of Infective Endocarditis in a Tertiary Hospital in China: A Retrospective Study.Infection and drug resistance · 2022Article
- Surgical treatment of valve endocarditis in high-risk patients and predictors of long-term outcomes.Scientific reports · 2021Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfective endocarditis (IE) is associated with high mortality. Surgery may improve survival and reduce complications, but the balance between benefit and harm is difficult and may be closely related to age and type of surgical intervention. We aimed to examine how age and type of left-sided surgical intervention modified mortality in patients undergoing surgery for IE.
methodsBy crosslinking nationwide Danish registries we identified patients with first-time IE undergoing surgical treatment 2000-2017. Patients were grouped by age < 60 years, 60-75 years, and ≥ 75 years. Multivariable adjusted Cox proportional hazard analysis was used to examine factors associated with 90-day mortality.
resultsWe included 1767 patients with IE undergoing surgery, 735 patients < 60 years (24.1% female), 766 patients 60-75 years (25.8% female), and 266 patients ≥75 years (36.1% female). The proportions of patients undergoing surgery were 35.3, 26.9, and 9.1% for patients < 60 years, 60-75 years, and > 75 years, respectively. Mortality at 90 days were 7.5, 13.9, and 22.3% (p < 0.001) for three age groups. In adjusted analyses, patients 60-75 years and patients ≥75 years were associated with a higher mortality, HR = 1.84 (95% CI: 1.48-2.29) and HR = 2.47 (95% CI: 1.88-3.24) as compared with patients < 60 years. Factors associated with 90-day mortality were: mitral valve surgery, a combination of mitral and aortic valve surgery as compared with isolated aortic valve surgery, age, diabetes, and prosthetic heart valve implantation prior to IE admission.
conclusionsIn patients undergoing surgery for IE, mortality increased significantly with age and 1 in 5 died above age 75 years. Mitral valve surgery as well as multiple valve interventions augmented mortality further.
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