ReviewNutrients2020
Protein Intake and Frailty: A Matter of Quantity, Quality, and Timing.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Association between frailty and hypoproteinaemia in older patients: meta-analysis and systematic review.BMC geriatrics · 2024Pooled it
- Pooled it
- Protein Intake and Sarcopenia in Older Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Protein Intake and Frailty in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2022Pooled it
- Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial.BMC geriatrics · 2025Trial
- Effects of Exergames and Protein Supplementation on Body Composition and Musculoskeletal Function of Prefrail Community-Dwelling Older Women: A Randomized, Controlled Clinical Trial.International journal of environmental research and public health · 2021Trial
- Trial
- Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults.European journal of nutrition · 2026Article
- Exploratory plasma metabolomics of aging-related associations with muscle quality and pulmonary function.GeroScience · 2026Article
- Associations between frailty severity and dietary quality and food security among older Korean adults: a cross-sectional study.BMC geriatrics · 2026Article
- The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.Metabolites · 2026Review
- Protein intake and its interaction with dietary patterns on clinical outcomes among older adults.npj aging · 2026Article
- Robot-Assisted Physical Exercise in Acutely Hospitalised Geriatric Patients: Insights From the ROBUST RCT - A Case Report.International medical case reports journal · 2026Article
- The role of protein quality and amino acid composition in preventing sarcopenia and functional decline in older adults.Frontiers in nutrition · 2026Review
- Development of a prediction model for identifying older adults with low protein using a simple food intake questionnaire.Journal of nutritional science · 2026Article
- Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches.International journal of molecular sciences · 2025Review
- Multidimensional determinants of active and healthy aging trajectories: a position paper from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Association Between Refrigerator Openings and Protein Intake After Hospitalization for Heart Failure Decompensation: Protocol for a Prospective Cohort Pilot Study.JMIR research protocols · 2025Article
- Association of health promotion behaviors with frailty in Chinese middle-aged and older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Time-restricted eating and cancer: lessons learned and considerations for a path forward.Journal of the National Cancer Institute · 2025Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Frailty is a geriatric syndrome that refers to a state of reduced resiliency to stressful events that occurs in response to physiological and/or psychosocial detriments. Frailty is a predictor of poor prognosis, given that frail older adults are at higher risk of many adverse health-related events. Hence, the identification of potential strategies to prevent the development and progression of frailty is of extreme importance for avoiding its negative outcomes. An adequate protein consumption is advocated as a possible intervention for the management of frailty in older adults due to its effects on muscle mass and physical function. However, empirical evidence is still needed to support this proposition. On the other hand, substantial evidence from observational studies has provided important information on the association between frailty and dietary protein-related parameters. Here, we provide a narrative review of the current literature regarding the association between protein intake (amount (how much?), quality (what type?), and distribution across meals (when?)) and frailty-related parameters. The ultimate aim of this work is to offer practical, evidence-based indications to healthcare professionals responsible for the care of frail older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.