ReviewExperientia1987
Peptides in the mammalian cardiovascular system.
Review in Experientia, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 99 citations in OpenAlex.
- TRPV1 deletion in male mice alters cardiomyocyte ultrastructure without affecting baseline cardiac function.Scientific reports · 2025Article
- Circulating mediators of remote ischemic preconditioning: search for the missing link between non-lethal ischemia and cardioprotection.Oncotarget · 2019Review
- Cancer induces cardiomyocyte remodeling and hypoinnervation in the left ventricle of the mouse heart.PloS one · 2011Article
- Formation of neuromuscular junctions and synthesis of sensory neuropeptides in the co-cultures of dorsal root ganglion and cardiac myocytes.Cellular and molecular neurobiology · 2008Article
- Distribution of the hypothalamic cardioactive hormone "G"-protein complex (PCG) in neuronal elements of the heart in intact and vagotomized rats.Neurochemical research · 2002Article
- Distribution of PGP 9.5, TH, NPY, SP and CGRP immunoreactive nerves in the rat and guinea pig atrioventricular valves and chordae tendineae.Journal of anatomy · 1997Article
- Distribution of peptide-containing neurons in the developing rat right atrium, studied using immunofluorescence and confocal laser scanning.Neurochemical research · 1997Article
- A quantitative study of nerve distribution in the conduction system of the guinea pig heart.Journal of anatomy · 1996Article
- Development of the peptidergic innervation of human heart.Journal of anatomy · 1993Article
- Postnatal development of the rat portal vein: correlation with occurrence of peptidergic innervation.Cell and tissue research · 1993Article
- Involvement of capsaicin-sensitive neurones in the haemodynamic effects of exogenous vasoactive peptides: studies in conscious, adult Long Evans rats treated neonatally with capsaicin.British journal of pharmacology · 1992Article
- X-irradiation attenuates relaxant responses in the rabbit ear artery.British journal of pharmacology · 1992Article
- Catecholamine-synthesizing enzymes and neuropeptides in rat heart epicardial ganglia; an immunohistochemical study.The Histochemical journal · 1990Article
- Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.British journal of pharmacology · 1990Article
- Some parasympathetic neurons in the guinea-pig heart express aspects of the catecholaminergic phenotype in vivo.Cell and tissue research · 1990Article
- Sensory nerves, vascular endothelium and neurogenic relaxation of the guinea-pig isolated pulmonary artery.Naunyn-Schmiedeberg's archives of pharmacology · 1990Article
- Review
- The pathological basis of angina pectoris.Cardiovascular drugs and therapy · 1989Review
- Vasoactive intestinal polypeptide-like immunoreactivity in the bovine heart: high degree of coexistence with neuropeptide Y-like immunoreactivity.Cell and tissue research · 1989Article
- Vasoactive intestinal polypeptide-immunoreactive nerves in the pulmonary vasculature of the aquatic file snake Acrochordus granulatus.Cell and tissue research · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ample immunocytochemical evidence is now available demonstrating that several peptides are present in the mammalian cardiovascular system where they are localised to nerve fibres and myocardial cells. The neuropeptides (neuropeptide Y, calcitonin gene-related peptide, tachykinins and vasoactive intestinal polypeptide) are localised to large secretory vesicles in subpopulations of afferent or efferent nerves supplying the heart and vasculature of several mammals, including man. Although they often exert potent pharmacological effects on the tissues in which they occur their physiological significance has still to be established. They may act directly via specific receptors and/or indirectly by influencing the release and action of other cardiovascular transmitters. In marked contrast, atrial natriuretic peptide is produced by cardiac myocytes and considered to act as a circulating hormone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.