Evidence map›Paper›PMID 32977642›Full record

ArticleMolecules (Basel, Switzerland)2020

Novel Harmicines with Improved Potency against

Marina Marinović, Ivana Perković, Diana Fontinha, Miguel Prudêncio, Jana Held, Lais Pessanha de Carvalho, Tana Tandarić, Robert Vianello, Branka Zorc, Zrinka Rajić

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Inhibitors of theCells · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marina MarinovićFaculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Ivana PerkovićFaculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.
Diana FontinhaInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0002-0046-648X
Miguel PrudêncioInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.ORCID 0000-0003-1746-6029
Jana HeldInstitute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany.
Lais Pessanha de CarvalhoInstitute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074 Tübingen, Germany.
Tana TandarićComputational Organic Chemistry and Biochemistry Group, Rudjer Bošković Institute, Bijenička cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-1430-5107
Robert VianelloComputational Organic Chemistry and Biochemistry Group, Rudjer Bošković Institute, Bijenička cesta 54, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-1779-4524
Branka ZorcFaculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-4355-8816
Zrinka RajićFaculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia.ORCID 0000-0003-1223-1116

Funding

Fundação para a Ciência e Tecnologia 02/SAICT/2017/29550Hrvatska Zaklada za Znanost UIP-2017-05-5160Hrvatska Zaklada za Znanost Young researcher's career development project - training of doctoral studentsSveučilište u Zagrebu support for 2019
6 · The paper itself

Abstract

Harmicines represent hybrid compounds composed of β-carboline alkaloid harmine and cinnamic acid derivatives (CADs). In this paper we report the synthesis of amide-type harmicines and the evaluation of their biological activity.

Indexed as

Adenosine TriphosphateAnimalsAntimalarialsFemaleHSP90 Heat-Shock ProteinsIndole AlkaloidsLiverMolecular Dynamics SimulationPlasmodium bergheiPlasmodium falciparumProtein ConformationAdenosine TriphosphateAntimalarialsharmicineHSP90 Heat-Shock ProteinsIndole Alkaloidsamideantiplasmodial activitycinnamic acidharminemolecular dynamics simulationsP. bergheiP. falciparumPfHsp90

Identifiers

PMID32977642
PMCPMC7583898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.