ReviewInternational journal of environmental research and public health2020
Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates.
Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- A Paternal Fish Oil Diet Preconception Modulates the Gut Microbiome and Attenuates Necrotizing Enterocolitis in Neonatal Mice.Marine drugs · 2022Trial
- [A prospective cohort study of gut microbiota changes in very preterm infants with bronchopulmonary dysplasia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Integrated multi-omics analysis to explore correlations among cord blood IGF-1 levels, metabolomic profiles, and meconium gut microbiota in small-for-gestational-age neonates.Frontiers in pediatrics · 2026Article
- A newborn derived monoclonal IgM antibody selectively modulates microbial metabolism in the gut.Nature communications · 2025Article
- Early-Life Development of the Intestinal Microbiome in Preterm and Term Infants Hospitalized in the Neonatal Intensive Care Unit.Microorganisms · 2025Article
- Changes in intestinal bacterial characteristics during hospitalization in the NICU in very low birth weight infants.Italian journal of pediatrics · 2025Article
- Microbial Metabolites and Cardiovascular Dysfunction: A New Era of Diagnostics and Therapy.Cells · 2025Review
- Review
- The Relationship Between Prematurity and Mode of Delivery with Disorders of Gut-Brain Interaction in Children.Children (Basel, Switzerland) · 2025Article
- Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate.Pediatric research · 2025Review
- Brain injury in premature infants may be related to abnormal colonization of early gut microbiome.BMC microbiology · 2024Article
- Intrauterine Shaping of Fetal Microbiota.Journal of clinical medicine · 2024Review
- Metabolic and Microbial Dysregulation in Preterm Infants with Neonatal Respiratory Distress Syndrome: An Early Developmental Perspective.Journal of proteome research · 2024Article
- The Relationship Between Gut Microbiome and Ophthalmologic Diseases: A Comprehensive Review.Cureus · 2024Review
- The Association between Delayed Gut Microbiota Maturity in Pre-Term Infants and the Feeding Intolerance-A Pilot Study.Biomedicines · 2024Article
- Review
- From Birth to Weaning: A Window of Opportunity for Microbiota.Nutrients · 2024Review
- Construction and validation of a risk prediction model for extrauterine growth restriction in preterm infants born at gestational age less than 34 weeks.Frontiers in pediatrics · 2024Article
- Neonatal Microbiome: Is it Still Beneficial?Endocrine, metabolic & immune disorders drug targets · 2024Article
- Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study.Frontiers in neuroscience · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mortality rate of very preterm infants with birth weight <1500 g is as high as 15%. The survivors till discharge have a high incidence of significant morbidity, which includes necrotising enterocolitis (NEC), early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS). More than 25% of preterm births are associated with microbial invasion of amniotic cavity. The preterm gut microbiome subsequently undergoes an early disruption before achieving bacterial maturation. It is postulated that bacterial gut colonisation at birth and postnatal intestinal dysbacteriosis precede the development of NEC and LONS in very preterm infants. In fact, bacterial colonization patterns in preterm infants greatly differ from term infants due to maternal chorioamnionitis, gestational age, delivery method, feeding type, antibiotic exposure and the environment factor in neonatal intensive care unit (NICU). In this regard, this review provides an overview on the gut bacteria in preterm neonates' meconium and stool. More than 50% of preterm meconium contains bacteria and the proportion increases with lower gestational age. Researchers revealed that the gut bacterial diversity is reduced in preterm infants at risk for LONS and NEC. Nevertheless, the association between gut dysbacteriosis and NEC is inconclusive with regards to relative bacteria abundance and between-sample beta diversity indices. With most studies show a disruption of the Proteobacteria and Firmicutes preceding the NEC. Hence, this review sheds light on whether gut bacteria at birth either alone or in combination with postnatal gut dysbacteriosis are associated with mortality and the morbidity of LONS and NEC in very preterm infants.
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Registered trials
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