Evidence map›Paper›PMID 32977594›Full record

ArticleNanomaterials (Basel, Switzerland)2020

pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery.

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Nanoscale Drug Delivery Systems in Glioblastoma.Nanoscale research letters · 2022
    Review
  6. Article
  7. Article
  8. Supramolecular Self-Associations of Amphiphilic Dendrons and Their Properties.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Review
  9. Review
  10. Review
  11. Advances in Nanomaterials in Biomedicine.Nanomaterials (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Evgeny ApartsinInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.ORCID 0000-0003-3334-0397
Nadezhda KnauerInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.ORCID 0000-0002-5877-3909
Valeria ArkhipovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.
Ekaterina PashkinaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.
Alina AktanovaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.
Julia PoletaevaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, Russia.
Javier Sánchez-NievesDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.ORCID 0000-0003-0410-2285
Francisco Javier de la MataDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.ORCID 0000-0003-0418-3935
Rafael GómezDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.
Institute of Chemical Biology and Fundamental Medicine · RUUniversidad de Alcalá · ESCentre National de la Recherche Scientifique · FRNovosibirsk State University · RU

Funding

Council on grants of the President of the Russian Federation MK-2278.2019.4European Cooperation in Science and Technology CA 17140 "Cancer Nanomedicine from the Bench to the Bedside"H2020 Marie Skłodowska-Curie Actions 844217Ministerio de Economía, Industria y Competitividad, Gobierno de España Consortium NANODENDMED-II-CM (B2017/BMD-3703)Ministerio de Economía, Industria y Competitividad, Gobierno de España CTQ-2017-85224-PMinisterio de Economía, Industria y Competitividad, Gobierno de España IMMUNOTHERCAN-CM (B2017/BMD3733)Russian Foundation for Basic Research 18-33-20209
6 · The paper itself

Abstract

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species-triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Indexed as

amphiphilecarbosilanedendrondoxorubicinleukaemiamethotrexatepH-sensitiveself-assemblytriazinevesicles

Identifiers

PMID32977594
PMCPMC7598245
OpenAlexW3088365399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.