Evidence map›Paper›PMID 32977518›Full record

ArticleInternational journal of molecular sciences2020

Synapse and Receptor Alterations in Two Different S100B-Induced Glaucoma-Like Models.

Lara Benning, Sabrina Reinehr, Pia Grotegut, Sandra Kuehn, Gesa Stute, H Burkhard Dick, Stephanie C Joachim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Single-Cell Transcriptomics onBiomedicines · 2025
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  3. Review
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  5. Article
  6. Towards an Understanding of Retinal Diseases and Novel Treatment.International journal of molecular sciences · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lara BenningExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Sabrina ReinehrExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Pia GrotegutExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Sandra KuehnExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Gesa StuteExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
H Burkhard DickExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.
Stephanie C JoachimExperimental Eye Research Institute, University Eye Hospital, Ruhr-University Bochum, In der Schornau 23-25, 44892 Bochum, Germany.ORCID 0000-0001-7056-0829
University Hospitals of the Ruhr-University of Bochum · DE

Funding

Deutsche Forschungsgemeinschaft JO-886/1-3Deutsche Ophthalmologische Gesellschaft none
6 · The paper itself

Abstract

Glaucoma is identified by an irreversible retinal ganglion cell (RGC) loss and optic nerve damage. Over the past few years, the immune system gained importance in its genesis. In a glaucoma-like animal model with intraocular S100B injection, RGC death occurs at 14 days. In an experimental autoimmune glaucoma model with systemic S100B immunization, a loss of RGCs is accompanied by a decreased synaptic signal at 28 days. Here, we aimed to study synaptic alterations in these two models. In one group, rats received a systemic S100B immunization (

Indexed as

AnimalsAutoimmune DiseasesDisease Models, AnimalGlaucomaIntraocular PressureMaleOptic NerveRatsRats, Inbred LewRats, WistarReceptors, GABAReceptors, N-Methyl-D-AspartateRetinal Ganglion CellsS100 Calcium Binding Protein beta SubunitSynapsesReceptors, GABAReceptors, N-Methyl-D-AspartateS100b protein, ratS100 Calcium Binding Protein beta Subunitanimal modelGABA receptorglaucomaintraocular injectionNMDA receptorS100B proteinsynapsessystemic immunization

Identifiers

PMID32977518
PMCPMC7583988
OpenAlexW3089060721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.