Homology Modeling and Optimized Expression of Truncated IK Protein, tIK, as an Anti-Inflammatory Peptide.

Yuyoung Song, Minseon Kim, Yongae Kim

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Structural Studies of Expressed tIK, Anti-Inflammatory Peptide.International journal of molecular sciences · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuyoung SongDepartment of Chemistry, Hankuk University of Foreign Studies, Yongin 17035, Korea.

Minseon KimDepartment of Chemistry, Hankuk University of Foreign Studies, Yongin 17035, Korea.

Yongae KimDepartment of Chemistry, Hankuk University of Foreign Studies, Yongin 17035, Korea.ORCID 0000-0001-6216-5132

Funding

National Research Foundation of Korea 2017012599National Research Foundation of Korea 2019090985

6 · The paper itself

Abstract

Rheumatoid arthritis, caused by abnormalities in the autoimmune system, affects about 1% of the population. Rheumatoid arthritis does not yet have a proper treatment, and current treatment has various side effects. Therefore, there is a need for a therapeutic agent that can effectively treat rheumatoid arthritis without side effects. Recently, research on pharmaceutical drugs based on peptides has been actively conducted to reduce negative effects. Because peptide drugs are bio-friendly and bio-specific, they are characterized by no side effects. Truncated-IK (tIK) protein, a fragment of IK protein, has anti-inflammatory effects, including anti-rheumatoid arthritis activity. This study focused on the fact that tIK protein phosphorylates the interleukin 10 receptor. Through homology modeling with interleukin 10, short tIK epitopes were proposed to find the essential region of the sequence for anti-inflammatory activity. T

Indexed as

Models, MolecularSequence HomologyAmino Acid SequenceAnimalsAnti-Inflammatory AgentsCell DifferentiationCell LineEpitopesGene ExpressionPeptidesProtein MultimerizationProtein Structure, QuaternaryTh17 CellsAnti-Inflammatory AgentsEpitopesPeptidesanti-inflammatory peptideautoimmune diseasesexpressionhomology modelinginterleukin-10rheumatoid arthritistruncated-IK protein (tIK protein)

Identifiers

PMID32977406

DOI10.3390/molecules25194358

PMCPMC7583991

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.