Evidence map›Paper›PMID 32976995›Full record

ArticleContemporary clinical trials2020

Working with HIV clinics to adopt addiction treatment using implementation facilitation (WHAT-IF?): Rationale and design for a hybrid type 3 effectiveness-implementation study.

E Jennifer Edelman, James Dziura, Denise Esserman, Elizabeth Porter, William C Becker, Philip A Chan, Deborah H Cornman, Gabriel Rebick, Jessica Yager, Kenneth Morford and 2 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Contemporary clinical trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02907944 (Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02907944 nacompletednot on this map

Working With HIV Clinics to Adopt Addiction Treatments Using Implementation Facilitation (WHAT-IF?)

TypeinterventionalSponsorYale UniversityRan2016 to 2021Enrolled3,838ConditionsSubstance-related DisordersArmsImplementation Facilitation
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Interventions for tobacco use cessation in people living with HIV.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

E Jennifer EdelmanProgram in Addiction Medicine, Yale School of Medicine, New Haven, CT, United States of America; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America; Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT, United States of America. Electronic address: ejennifer.edelman@yale.edu.
James DziuraYale Center for Analytic Sciences, Yale School of Public Health, New Haven, CT, United States of America; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, United States of America.
Denise EssermanYale Center for Analytic Sciences, Yale School of Public Health, New Haven, CT, United States of America; Department of Biostatistics, Yale School of Public Health, New Haven, CT, United States of America.
Elizabeth PorterDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America.
William C BeckerProgram in Addiction Medicine, Yale School of Medicine, New Haven, CT, United States of America; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America; VA Connecticut Healthcare System, West Haven, CT, United States of America.
Philip A ChanDepartment of Medicine, Brown University, Providence, RI, United States of America.
Deborah H CornmanInstitute for Collaboration on Health, Intervention, and Policy (InCHIP), University of Connecticut, Storrs, CT, United States of America.
Gabriel RebickNew York University, New York, NY, United States of America.
Jessica YagerSUNY Downstate, Brooklyn, NY, United States of America.
Kenneth MorfordProgram in Addiction Medicine, Yale School of Medicine, New Haven, CT, United States of America; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America.
Srinivas B MuvvalaProgram in Addiction Medicine, Yale School of Medicine, New Haven, CT, United States of America; Department of Psychiatry, Yale School of Medicine, New Haven, CT, United States of America.
David A FiellinProgram in Addiction Medicine, Yale School of Medicine, New Haven, CT, United States of America; Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States of America; Center for Interdisciplinary Research on AIDS, Yale School of Public Health, New Haven, CT, United States of America; Department of Emergency Medicine, Yale School of Medicine, New Haven, CT, United States of America.
Yale University · USBrown University · USNew York University · USSUNY Downstate Health Sciences University · USUniversity of Connecticut · USVA Connecticut Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Drug use, Addiction and HIV Research Scholars (DAHRS)K12DA033312 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Patrick O'Connor · 2013 to 2026
$7.2M
Working with HIV clinics to adopt addiction treatments using Implementation Facilitation (WHAT IF?)R01DA041067 · NIDA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2015 to 2019
$2.9M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K12 DA033312NIDA NIH HHS R01 DA041067
6 · The paper itself

Abstract

backgroundTobacco, alcohol and opioid misuse are associated with substantial morbidity and mortality among people with HIV (PWH). Despite existence of evidence-based counseling and medications for addiction, these treatments are infrequently offered in HIV clinics. The Working with HIV clinics to adopt Addiction Treatment using Implementation Facilitation (WHAT-IF?) study was conducted to address this implementation challenge. The study's goals were to conduct a formative evaluation of barriers to and facilitators of implementing addiction treatment for PWH followed by an evaluation of the impact of Implementation Facilitation (IF) on promoting adoption of addiction treatments and clinical outcomes.

methodsThe study was conducted at four HIV clinics in the northeast United States, using a hybrid type 3 effectiveness-implementation stepped wedge design and guided by the Promoting Action on Research Implementation in Health Services Research (PARiHS) framework. A mixed-methods approach was used to identify evidence, context, and facilitation-related barriers to and facilitators of integration of addiction treatments into HIV clinics and to help tailor IF for each clinic. An evaluation was then conducted of the impact of IF on implementation outcomes, including provision of addiction treatment (primary outcome), organizational and clinician and staff readiness to adopt addiction treatment, and changes in organizational models of care used to deliver addiction treatment. The evaluation also included IF's impact on effectiveness outcomes, specifically HIV-related outcomes among patients eligible for addiction treatment.

conclusionsResults will generate important information regarding the impact of IF as a reproducible strategy to promote addiction treatment in HIV clinics.

Indexed as

HIV InfectionsOpioid-Related DisordersAmbulatory Care FacilitiesCounselingHumansHIVHybrid designImplementation scienceSubstance-related disorders

Identifiers

PMID32976995
PMCPMC7511156
OpenAlexW3088030677

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.