Observational studyCurrent biology : CB2020
Transient Disruption of the Inferior Parietal Lobule Impairs the Ability to Attribute Intention to Action.
Observational study in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer's Disease.The journal of prevention of Alzheimer's disease · 2026Pooled it
- The shared neural substrates of emotional mimicry and emotional contagion: an activation likelihood estimation meta-analysis and meta-analytic connectivity modeling analysis.Social cognitive and affective neuroscience · 2025Pooled it
- Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Disruption of dopamine D2/D3 system function impairs the human ability to understand the mental states of other people.PLoS biology · 2024Trial
- Selective perturbation of mirror and non-mirror neurons in an in silico model of the action observation network.iScience · 2026Article
- Reduced inter-subject functional connectivity during movies in autism: replicability across cross-national fMRI datasets.Molecular autism · 2026Article
- Discourse Context and Co-Speech Gestures Jointly Shape Hierarchical Prediction During the Processing of a Multimodal Narrative.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Disentangling the Functional Roles of Premotor-Motor Pathways in Automatic Imitation: A Combined Network-Based Transcranial Stimulation and Drift Diffusion Modeling Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The individual training history shapes soccer players' ability to predict teammates' and opponents' moves.Scientific reports · 2025Article
- Article
- Decoding affect in emotional body language: valence representation in the action observation network.Social cognitive and affective neuroscience · 2025Article
- How choice and motor mimicry affect affiliation: An fNIRS study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dissociating goal from outcome during action observation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Contextual Priors Shape Action Understanding before and beyond the Unfolding of Movement Kinematics.Brain sciences · 2024Article
- The Role of Agentive and Physical Forces in the Neural Representation of Motion Events.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Action prediction in psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Action observation reveals a network with divergent temporal and parietal cortex engagement in dogs compared with humans.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Visuo-motor interference is modulated by task interactivity: A kinematic study.Psychonomic bulletin & review · 2023Article
- Kinematic priming of action predictions.Current biology : CB · 2023Article
- How the conception of control influences our understanding of actions.Nature reviews. Neuroscience · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Although it is well established that fronto-parietal regions are active during action observation, whether they play a causal role in the ability to infer others' intentions from visual kinematics remains undetermined. In the experiments reported here, we combined offline continuous theta burst stimulation (cTBS) with computational modeling to reveal and causally probe single-trial computations in the inferior parietal lobule (IPL) and inferior frontal gyrus (IFG). Participants received cTBS over the left anterior IPL and the left IFG pars orbitalis in separate sessions before completing an intention discrimination task (discriminate intention of observed reach-to-grasp acts) or a kinematic discrimination task unrelated to intention (discriminate peak wrist height of the same acts). We targeted intention-sensitive regions whose fMRI activity, recorded when observing the same reach-to-grasp acts, could accurately discriminate intention. We found that transient disruption of activity of the left IPL, but not the IFG, impaired the observer's ability to attribute intention to action. Kinematic discrimination unrelated to intention, in contrast, was largely unaffected. Computational analyses of how encoding (mapping of intention to movement kinematics) and readout (mapping of kinematics to intention choices) intersect at the single-trial level revealed that IPL cTBS did not diminish the overall sensitivity of intention readout to movement kinematics. Rather, it selectively misaligned intention readout with respect to encoding, deteriorating mapping from informative kinematic features to intention choices. These results provide causal evidence of how the left anterior IPL computes mapping from kinematics to intentions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.