Evidence map›Paper›PMID 32976770›Full record

ArticleNeuron2020

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.

Christian Henneberger, Lucie Bard, Aude Panatier, James P Reynolds, Olga Kopach, Nikolay I Medvedev, Daniel Minge, Michel K Herde, Stefanie Anders, Igor Kraev and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 263 citations in OpenAlex.

  1. Review
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  5. Astrocyte TrkB.T1 Deficiency Disrupts Glutamatergic Synaptogenesis and Astrocyte-Synapse Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Review
  7. Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026
    Review
  8. Article
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  10. Review
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  12. Review
  13. Engineering Microbial Particles for Next-Generation Biomedical Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Review
  15. Article
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  17. Article
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  19. Review
  20. Review

87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 7 countries.

Christian HennebergerUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; Institute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany. Electronic address: christian.henneberger@uni-bonn.de.
Lucie BardUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Aude PanatierINSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France.
James P ReynoldsUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Olga KopachUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Nikolay I MedvedevLife Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Daniel MingeInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Michel K HerdeInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Stefanie AndersInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Igor KraevLife Sciences, The Open University, Milton Keynes MK7 6AA, UK.
Janosch P HellerUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Sylvain RamaUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Kaiyu ZhengUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Thomas P JensenUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Inmaculada Sanchez-RomeroInstitute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Colin J JacksonResearch School of Chemistry, Australian National University, Acton, ACT 2601, Australia.
Harald JanovjakInstitute of Science and Technology Austria, 3400 Klosterneuburg, Austria; EMBL Australia, Australian Regenerative Medicine Institute, Faculty of Medicine, Nursing and Health Science, Monash University, Melbourne, VIC 3800, Australia.
Ole Petter OttersenInstitute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; Karolinska Institutet, 171 77 Stockholm, Sweden.
Erlend Arnulf NagelhusInstitute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Stephane H R OlietINSERM U1215, Neurocentre Magendie, 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France.
Michael G StewartLife Sciences, The Open University, Milton Keynes MK7 6AA, UK. Electronic address: m.g.stewart@open.ac.uk.
U Valentin NägerlUniversité de Bordeaux, 33000 Bordeaux, France; Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, 33000 Bordeaux, France. Electronic address: valentin.nagerl@u-bordeaux.fr.
Dmitri A RusakovUCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK. Electronic address: d.rusakov@ucl.ac.uk.
National Hospital for Neurology and Neurosurgery · GBUniversity of Bonn · DEThe Open University · GBCentre National de la Recherche Scientifique · FRInstitute of Science and Technology Austria · ATUniversity of Oslo · NOAustralian National University · AUMRC Prion Unit · GBUniversité de Bordeaux · FR

Funding

Wellcome TrustWellcome Trust 101896Wellcome Trust 212251
6 · The paper itself

Abstract

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circuits. Memory formation in the brain is associated with synaptic remodeling, but how this affects PAPs and therefore extrasynaptic glutamate actions is poorly understood. Here, we used advanced imaging methods, in situ and in vivo, to find that a classical synaptic memory mechanism, long-term potentiation (LTP), triggers withdrawal of PAPs from potentiated synapses. Optical glutamate sensors combined with patch-clamp and 3D molecular localization reveal that LTP induction thus prompts spatial retreat of astroglial glutamate transporters, boosting glutamate spillover and NMDA-receptor-mediated inter-synaptic cross-talk. The LTP-triggered PAP withdrawal involves NKCC1 transporters and the actin-controlling protein cofilin but does not depend on major Ca

Indexed as

AnimalsAstrocytesFemaleGlutamic AcidImaging, Three-DimensionalLong-Term PotentiationMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicOrgan Culture TechniquesRatsRats, Sprague-DawleyRats, WistarSynapsesGlutamic Acidastrocyte plasticitybarrel cortexExcitatory synapseglutamate sensor imagingglutamate spilloverhippocampuslong-term potentiationperisynaptic astroglial processessuper-resolution microscopywhisker stimulation

Identifiers

PMID32976770
PMCPMC7736499
OpenAlexW3087901293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.