ArticleBiophysical journal2020
Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Investigating local negative feedback of Rac activity by mathematical models and cell-motility simulations.iScience · 2026Article
- Spatiotemporal coupling of caveolae mechanosensing and RhoA-GEFs regulates cell polarity and directional migration.Nature communications · 2025Article
- Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement.Current opinion in cell biology · 2024Review
- Article
- Understanding the interplay of membrane trafficking, cell surface mechanics, and stem cell differentiation.Seminars in cell & developmental biology · 2023Review
- Unravelling cell migration: defining movement from the cell surface.Cell adhesion & migration · 2022Review
- Cortical tension initiates the positive feedback loop between cadherin and F-actin.Biophysical journal · 2022Article
- Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells.PLoS computational biology · 2021Article
- Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells.Frontiers in immunology · 2021Review
- A free boundary mechanobiological model of epithelial tissues.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. Although biochemical models of adaptation have been previously proposed, here, we discuss a different mechanism based on mechanosensing, in which the interaction between biochemical signaling and cell tension facilitates adaptation. We describe and analyze a model of mechanochemical-based adaptation coupling a mechanics-based physical model of cell tension coupled with the wave-pinning reaction-diffusion model for Rac GTPase activity. The mathematical analysis of this model, simulations of a simplified one-dimensional cell geometry, and two-dimensional finite element simulations of deforming cells reveal that as a cell protrudes under the influence of high stimulation levels, tension-mediated inhibition of Rac signaling causes the cell to polarize even when initially overstimulated. Specifically, tension-mediated inhibition of Rac activation, which has been experimentally observed in recent years, facilitates this adaptation by countering the high levels of environmental stimulation. These results demonstrate how tension-related mechanosensing may provide an alternative (and potentially complementary) mechanism for cell adaptation.
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