ArticlePLoS computational biology2020
Short-term depression and long-term plasticity together tune sensitive range of synaptic plasticity.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.Ageing research reviews · 2022Pooled it
- A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity.PLoS computational biology · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Memory under siege: the cognitive costs of smoking and vaping.Brain, behavior, & immunity - health · 2025Review
- Heterointerface-Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment.Frontiers in pharmacology · 2025Review
- Emergent functions of noise-driven spontaneous activity: homeostatic maintenance of criticality and memory consolidation.Frontiers in neural circuits · 2025Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Temperature effect on a weighted vortex spin-torque nano-oscillator for neuromorphic computing.Scientific reports · 2024Article
- Making time and space for calcium control of neuron activity.Current opinion in neurobiology · 2023Review
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- An in silico and in vitro human neuronal network model reveals cellular mechanisms beyond NaStem cell reports · 2023Article
- An ex vivo Model of Paired Cultured Hippocampal Neurons for Bi-directionally Studying Synaptic Transmission and Plasticity.Bio-protocol · 2023Article
- Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling.NPJ systems biology and applications · 2023Article
- Inhibitory neurons control the consolidation of neural assemblies via adaptation to selective stimuli.Scientific reports · 2023Article
- Neuromorphic learning, working memory, and metaplasticity in nanowire networks.Science advances · 2023Article
- Visuo-Acoustic Stimulation's Role in Synaptic Plasticity: A Review of the Literature.International journal of molecular sciences · 2021Review
Corrections and comments
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic efficacy is subjected to activity-dependent changes on short- and long time scales. While short-term changes decay over minutes, long-term modifications last from hours up to a lifetime and are thought to constitute the basis of learning and memory. Both plasticity mechanisms have been studied extensively but how their interaction shapes synaptic dynamics is little known. To investigate how both short- and long-term plasticity together control the induction of synaptic depression and potentiation, we used numerical simulations and mathematical analysis of a calcium-based model, where pre- and postsynaptic activity induces calcium transients driving synaptic long-term plasticity. We found that the model implementing known synaptic short-term dynamics in the calcium transients can be successfully fitted to long-term plasticity data obtained in visual- and somatosensory cortex. Interestingly, the impact of spike-timing and firing rate changes on plasticity occurs in the prevalent firing rate range, which is different in both cortical areas considered here. Our findings suggest that short- and long-term plasticity are together tuned to adapt plasticity to area-specific activity statistics such as firing rates.
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