ArticleSexually transmitted diseases2020
Exploring How Epidemic Context Influences Syphilis Screening Impact: A Mathematical Modeling Study.
Article in Sexually transmitted diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Mechanisms, management and prevention of anorectal sexually transmitted infections.Nature reviews. Gastroenterology & hepatology · 2026Review
- Evaluating syphilis transmission among MSM population: a mathematical model for reinfection, two-stage treatment, and treatment failure.Frontiers in public health · 2026Article
- Modeling the Impact of Time to Treatment on Syphilis Prevalence: A Theoretical Mathematical Model of People Living With HIV in Colombia.Sexually transmitted diseases · 2025Article
- Syphilis testing, incidence, and reinfection among gay and bisexual men in Australia over a decade spanning HIV PrEP implementation: an analysis of surveillance data from 2012 to 2022.The Lancet regional health. Western Pacific · 2024Article
- Management of asymptomatic sexually transmitted infections in Europe: towards a differentiated, evidence-based approach.The Lancet regional health. Europe · 2023Review
- Estimation of the Lifetime Quality-Adjusted Life Years (QALYs) Lost Due to Syphilis Acquired in the United States in 2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Cost-effectiveness of implementing HIV and HIV/syphilis dual testing among key populations in Viet Nam: a modelling analysis.BMJ open · 2022Article
- HIV, syphilis, hepatitis B and C in key populations: results of a 10-year cross-sectional study, Southern Brazil.Einstein (Sao Paulo, Brazil) · 2022Article
- A Decade of the National Center for HIV, Viral Hepatitis, STD, and TB Prevention's Epidemiologic and Economic Modeling Agreement.Public health reports (Washington, D.C. : 1974)Article
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe current syphilis epidemic in the United States is concentrated in gay, bisexual, and other men who have sex with men (MSM), but substantial heterosexual transmission is reported in some parts of the country. Using the US states of Louisiana and Massachusetts as case studies, we investigated how epidemic context influences the impact of population screening approaches for syphilis control.
methodsWe constructed a compartmental metapopulation model parameterized to describe observed patterns of syphilis transmission. We estimated the impact of different approaches to screening, including perfect adherence to current US screening guidelines in MSM.
resultsIn Louisiana, where syphilis cases are more evenly distributed among MSM and heterosexual populations, we projected that screening according to guidelines would contribute to no change or an increase in syphilis burden, compared with burden with current estimated screening coverage. In Massachusetts, which has a more MSM-focused outbreak, we projected that screening according to guidelines would be as or more effective than current screening coverage in most population groups.
conclusionsMen who have sex with men-focused approaches to screening may be insufficient for control when there is substantial transmission in heterosexual populations. Epidemic characteristics may be useful when identifying at-risk groups for syphilis screening.
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