ReviewDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]2020
Insights Into the Pathophysiology of Cellulite: A Review.
Review in Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Minimally Invasive Active Release of Septa Bands for Cellulite and Connective Tissue Release for Fibrosis Treatment in Body Contouring Surgery
Efficacy of Alidya Needle Mesotherapy in the Treatment of Cellulite: A Prospective Multimodal Clinical and Instrumental Evaluation
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative Analysis of Cellulite Treatment Modalities: A Systematic Review.Aesthetic plastic surgery · 2025Pooled it
- The Efficacy and Safety of Synchronous Parallel Ultrasound for the Clinical Improvement of Cellulite Using High-Density Handpiece.Journal of cosmetic dermatology · 2025Trial
- Clinical and Ultrasound Efficacy of Topical Hypertonic Cream (Jovita OsmocellMedicina (Kaunas, Lithuania) · 2024Trial
- Article
- Article
- The Role of Ultrasound in the Diagnosis and Treatment of Cellulite: A Systematic Review.Journal of clinical medicine · 2026Review
- Validation of Infrared Thermal Imaging for Grading of Cellulite Severity: Correlation with Clinical and Anthropometric Assessments.Journal of clinical medicine · 2026Article
- An Innovative Injection Technique for Treating Edematous Fibrosclerotic Panniculopathy (Cellulite): A Prospective Multicenter Clinical Investigation.Aesthetic surgery journal. Open forum · 2026Article
- Using High Frequency Ultrasound to Assess the Efficacy of Anti-Cellulite Treatments.Clinical, cosmetic and investigational dermatology · 2025Article
- High-Frequency Ultrasound in the Assessment of Cellulite-Correlation between Ultrasound-Derived Measurements, Clinical Assessment, and Nürnberger-Müller Scale Scores.Diagnostics (Basel, Switzerland) · 2024Article
- Comparing Collagenase and Tissue Subcision for Cellulite Treatment of the Buttock and Thigh Regions: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2024Article
- Review
- Safety and Efficacy of Diluted Calcium Hydroxylapatite for the Treatment of Cellulite Dimpling on the Buttocks: Results from an Open-Label, Investigator-Initiated, Single-Center, Prospective Clinical Study.Aesthetic plastic surgery · 2024Article
- A Clinical Guide to the Treatment of Cellulite and Comprehensive Review of the Etiology, Pathophysiology, and Utility of Intervention.Aesthetic plastic surgery · 2024Review
- Square technique-A treatment for cellulite with large size particle hyaluronic acid.Skin health and disease · 2024Article
- Cellulite and the Aesthetic Management of the Buttocks and Thighs: 6 Cases Illustrating Targeted Verifiable Subcision as Part of a Multimodal Approach to Lower Body Rejuvenation.Aesthetic surgery journal. Open forum · 2024Article
- Hyperdilute calcium hydroxyapatite for treatment of cellulite dimples in the buttock.JAAD case reports · 2023Article
- Multicenter Pivotal Study Demonstrates Safety and Efficacy of a New Cellulite Procedure: Final Results at 12 Months.Aesthetic surgery journal · 2023Article
- Multicenter Pivotal Study Demonstrates Safety and Efficacy of a New Cellulite Procedure: 3-Month Results.Aesthetic surgery journal · 2023Article
- Cellulite: Current Understanding and Treatment.Aesthetic surgery journal. Open forum · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe etiology of cellulite is unclear. Treatment of cellulite has targeted adipose tissue, dermis, and fibrous septae with varying degrees of success and durability of response.
objectiveResults from clinical trials that target different anatomical aspects of cellulite can provide insights into the underlying pathophysiology of cellulite. MATERIALS AND
methodsA search of the PubMed database and ClinicalTrials.gov website was conducted to identify clinical trials that have investigated treatments for cellulite.
resultsA lack of trial protocol standardization, objective means for quantification of improvement and reported cellulite severity, and short-term follow-up, as well as variation in assessment methods have made comparisons among efficacy studies challenging. However, the lack of durable efficacy and inconsistency seen in clinical results suggest that dermal or adipose tissue changes are not the primary etiologies of cellulite. Clinical studies targeting the collagen-rich fibrous septae in cellulite dimples through mechanical, surgical, or enzymatic approaches suggest that targeting fibrous septae is the strategy most likely to provide durable improvement of skin topography and the appearance of cellulite.
conclusionThe etiology of cellulite has not been completely elucidated. However, there is compelling clinical evidence that fibrous septae play a central role in the pathophysiology of cellulite.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.