ArticleCellular microbiology2021
Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans.
Article in Cellular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Acute pancreatitis gut dysbiosis persists at 1-year follow-up and is associated with clinical outcomes.Journal of pediatric gastroenterology and nutrition · 2025Article
- Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis.Nature communications · 2024Article
- Article
- Chemical biology tools to probe bacterial glycans.Current opinion in chemical biology · 2024Review
- The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids.Nature communications · 2024Article
- Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease.International journal of molecular medicine · 2023Article
- Shedding Light on Bacterial Physiology with Click Chemistry.Israel journal of chemistry · 2023Article
- Chemical tools to study bacterial glycans: a tale from discovery of glycoproteins to disruption of their function.Israel journal of chemistry · 2023Article
- Resistance is futile? Mucosal immune mechanisms in the context of microbial ecology and evolution.Mucosal immunology · 2022Review
- Azido Groups Hamper Glycan Acceptance by Carbohydrate Processing Enzymes.ACS central science · 2022Article
- Gut microbial response to host metabolic phenotypes.Frontiers in nutrition · 2022Review
- Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome.Scientific reports · 2021Article
- Intestinal inflammation alters mucosal carbohydrate foraging and monosaccharide incorporation into microbial glycans.Cellular microbiology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous carbohydrates released from the intestinal mucus represent a constant source of nutrients to the intestinal microbiota. Mucus-derived carbohydrates can also be used as building blocks in the biosynthesis of bacterial cell wall components, thereby influencing host mucosal immunity. To assess the uptake of endogenous carbohydrates by gut microbes in healthy mice and during intestinal inflammation, we applied azido-monosaccharides that can be tracked on bacterial cell walls after conjugation with fluorophores. In interleukin-10 deficient mice, changes in the gut microbiota were accompanied by decreased carbohydrate hydrolase activities and increased lumenal concentrations of host glycan-derived monosaccharides. Tracking of the monosaccharide N-azidoacetylglucosamine (GlcNAz) in caecum bacteria revealed a preferential incorporation of this carbohydrate by Xanthomonadaceae in healthy mice and by Bacteroidaceae in interleukin-10 deficient mice. These GlcNAz-positive Bacteroidaceae fractions mainly belonged to the species B. acidifaciens and B. vulgatus. Growth of Bacteroides species in the presence of specific monosaccharides changed their stimulatory activity toward CD11c
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