ArticleAngewandte Chemie (International ed. in English)2021
Diversification of Unprotected Alicyclic Amines by C-H Bond Functionalization: Decarboxylative Alkylation of Transient Imines.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Deciphering competing reaction pathways in the α-C-H functionalization of unprotected alicyclic aminesOrganic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Heterogeneous photocatalytic aldehyde alkylative amination for multicomponent synthesis of α-branched amines.National science review · 2026Article
- Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions.Molecules (Basel, Switzerland) · 2025Review
- Cyclic Imine-BFSynlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- Photocatalytic Decarboxylative Alkylation of Cyclic Imine-BFJournal of the American Chemical Society · 2024Article
- Regioselective α-Phosphonylation of Unprotected Alicyclic Amines.Organic letters · 2024Article
- Copper-Nitroxyl-Catalyzed α-Oxygenation of Cyclic Secondary Amines Including Application to Late-Stage Functionalization.Journal of the American Chemical Society · 2024Article
- Alicyclic-Amine-Derived Imine-BFAngewandte Chemie (International ed. in English) · 2024Article
- Palladium-Catalyzed Arylation of Endocyclic 1-Azaallyl Anions: Concise Synthesis of Unprotected Enantioenriched cis-2,3-Diarylpiperidines.Angewandte Chemie (International ed. in English) · 2023Article
- Article
- Regioselective α-Cyanation of Unprotected Alicyclic Amines.Organic letters · 2022Article
- Recent progress in the chemistry of β-aminoketones.RSC advances · 2022Review
- Synthesis of Polycyclic Isoindolines via α-C-H/N-H Annulation of Alicyclic Amines.Organic letters · 2022Article
- α,α'-C-H Bond Difunctionalization of Unprotected Alicyclic Amines.Organic letters · 2021Article
- α-C-H/N-H Annulation of Alicyclic Amines via Transient Imines: Preparation of Polycyclic Lactams.Organic letters · 2021Article
- α-C-H Bond Functionalization of Unprotected Alicyclic Amines: Lewis-Acid-Promoted Addition of Enolates to Transient Imines.Organic letters · 2021Article
- C-H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods.SynOpen (2017) · 2021Article
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Authors and funding
4 authors.
Funding
Abstract
Despite extensive efforts by many practitioners in the field, methods for the direct α-C-H bond functionalization of unprotected alicyclic amines remain rare. A new advance in this area utilizes N-lithiated alicyclic amines. These readily accessible intermediates are converted to transient imines through the action of a simple ketone oxidant, followed by alkylation with a β-ketoacid under mild conditions to provide valuable β-amino ketones with unprecedented ease. Regioselective α'-alkylation is achieved for substrates with existing α-substituents. The method is further applicable to the convenient one-pot synthesis of polycyclic dihydroquinolones through the incorporation of a S
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